Hippocampus and amygdala volumes in a random community-based sample of 60-64 year olds and their relationship to cognition

Jerome J. Maller; Kaarin J. Anstey; Chantal Reglade-Meslin; Helen Christensen; Wei Wen; Perminder Sachdev

doi:10.1016/j.pscychresns.2007.06.005

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Hippocampus and amygdala volumes in a random community-based sample of 60-64 year olds and their relationship to cognition

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Hippocampus and amygdala volumes in a random community-based sample of 60-64 year olds and their relationship to cognition

Jerome J. Maller, Kaarin J. Anstey, Chantal Reglade-Meslin, Helen Christensen, Wei Wen and Perminder Sachdev

Psychiatry research. Neuroimaging, Vol.156(3), pp.185-197

12/15/2007

DOI: 10.1016/j.pscychresns.2007.06.005

PMID: 17988837

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Abstract

Reduced volumes of the hippocampus (HQ and amygdala (AG) are potential biomarkers for Alzheimer's disease (AD) and other neuropsychiatric disorders. Published studies on HC and AG volumes suffer from methodological limitations, and a valid and reliable normative database does not exist. This study aimed to establish a. database of HC and AG volumes from a large community sample of participants 60-64 years old and relate them to cognition. A total of 452 randomly selected participants (from 622 approached) were retained in the study (238 males, 214 females), and all received brain MRI scans, as well as cognitive and physical assessments. HC and AG volumes were estimated from manual tracings on T1-weighted images, and intracranial volume (ICV) was obtained from an automated program. In both sexes, right hippocampi were larger than left, while left amygdalae were larger than right. The only correlation to remain significant after normalization was left HC volume and percent retention of a word list in females. This study provides a HC and AG volumetrics database and describes its relationship with cognitive performance in a representative sample using a standard methodology that will be a reference for future studies. It will therefore have clinical applicability in early AD and other disorders. (c) 2007 Elsevier Ireland Ltd. All rights reserved.

Clinical Neurology

Life Sciences & Biomedicine

Neuroimaging

Neurosciences & Neurology

Psychiatry

Science & Technology

Details

Title: Subtitle: Hippocampus and amygdala volumes in a random community-based sample of 60-64 year olds and their relationship to cognition
Creators: Jerome J. Maller - Australian National University
Kaarin J. Anstey - Australian National University
Chantal Reglade-Meslin - Australian National University
Helen Christensen - Australian National University
Wei Wen - Prince of Wales Hospital
Perminder Sachdev - Prince of Wales Hospital
Resource Type: Journal article
Publication Details: Psychiatry research. Neuroimaging, Vol.156(3), pp.185-197
DOI: 10.1016/j.pscychresns.2007.06.005
PMID: 17988837
NLM abbreviation: Psychiatry Res Neuroimaging
ISSN: 0925-4927
eISSN: 1872-7506
Publisher: Elsevier
Number of pages: 13
Language: English
Date published: 12/15/2007
Academic Unit: Radiology
Record Identifier: 9984848507202771

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