Journal article
Hispanic ethnicity and acculturation, maternal age and the risk of gastroschisis in the national birth defects prevention study
Birth defects research. A Clinical and molecular teratology, Vol.97(8), pp.538-545
08/2013
DOI: 10.1002/bdra.23140
PMID: 23729355
Abstract
Introduction
Studies indicate that gastroschisis is associated with maternal age, ethnicity, and acculturation. This analysis was conducted to further define the associations between gastroschisis and parental Hispanic ethnicity and acculturation, and to determine whether such associations vary by maternal age.
Methods:
This study was based on data from mothers of 753 gastroschisis cases and 6,496 control infants in the National Birth Defects Prevention Study. The relationships between gastroschisis and both parental Hispanic ethnicity and acculturation, within maternal age strata (<20 versus ≥20 years at conception), were assessed using logistic regression and principal component analyses.
Results:
The risk of gastroschisis in offspring of women <20 years old was not significantly associated with parental Hispanic ethnicity or acculturation. Among mothers ≥20 years old, US‐born non‐Hispanic white parents had a lower risk of gastroschisis in offspring as compared to either US‐born Hispanic (odds ratios [ORs] ranging from 0.55 to 0.60) or English‐speaking Hispanic (ORs ranging from 0.58 to 0.65) parents. Further, compared with US born Hispanic women ≥20 years, the risk of gastroschisis was lower for Hispanic women who had lived in the US <5 years (OR=0.35, 95% confidence interval [CI]: 0.17, 0.74) or who migrated to the US at ≥20 years (OR=0.47, 95% CI: 0.25, 0.88).
Conclusion:
These results provide further evidence that gastroschisis risk is associated with ethnicity and some aspects of acculturation. Additionally, these associations were limited to the offspring of women who are ≥20 at the time of conception. Birth Defects Research (Part A) 97:538‐545, 2013. © 2013 Wiley Periodicals, Inc.
Details
- Title: Subtitle
- Hispanic ethnicity and acculturation, maternal age and the risk of gastroschisis in the national birth defects prevention study
- Creators
- Zeina G Khodr - Human Genetics and Environmental Sciences, University of Texas School of Public HealthPhilip J Lupo - University of Texas School of Public HealthMark A Canfield - Texas Department of State Health ServicesWenyaw Chan - University of Texas school of Public HealthYi Cai - University of Texas school of Public HealthLaura E Mitchell - University of Texas School of Public HealthNational Birth Defects Prevention Study
- Contributors
- Paul A Romitti (Contributor) - University of Iowa, Epidemiology
- Resource Type
- Journal article
- Publication Details
- Birth defects research. A Clinical and molecular teratology, Vol.97(8), pp.538-545
- DOI
- 10.1002/bdra.23140
- PMID
- 23729355
- NLM abbreviation
- Birth Defects Res A Clin Mol Teratol
- ISSN
- 1542-0752
- eISSN
- 1542-0760
- Publisher
- Wiley
- Number of pages
- 8
- Grant note
- Supported by a cooperative agreement (U01DD000494) between the Centers for Disease Control and Prevention and the Texas Department of State Health Services (DSHS), and Maternal and Child Health Block Grants Funds from the Offices of Title V and Family Health, Texas DSHS
- Language
- English
- Date published
- 08/2013
- Academic Unit
- Epidemiology; Biostatistics
- Record Identifier
- 9984214671702771
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