Journal article
Histamine H 2 Receptor Antagonists and Heart Failure Risk in Postmenopausal Women: The Women's Health Initiative
Journal of the American Heart Association, Vol.11(5), p.e024270
03/2022
DOI: 10.1161/JAHA.121.024270
PMCID: PMC9075064
PMID: 35191329
Abstract
Background Prior studies suggested lower risk of heart failure (HF) in individuals taking H
receptor antagonists (H2RA) compared with H2RA nonusers in relatively small studies. We evaluated the association of H2RA use and incident HF in postmenopausal women in the large-scale WHI (Women's Health Initiative) study. Methods and Results This study included postmenopausal women from the WHI without a history of HF at baseline. HF was defined as first incident hospitalization for HF and physician adjudicated. Multivariable Cox proportional hazards regression models evaluated the association of H2RA use as a time-varying exposure with HF risk, after adjustment for demographic, lifestyle, and medical history variables. Sensitivity analyses examined (1) risk of HF stratified by the ARIC (Atherosclerosis Risk in Communities) score, (2) propensity score matching on H2RA use, (3) use of proton pump inhibitors rather than H2RA nonuse as the referent, and (4) exclusion of those taking diuretics at baseline. The primary analysis included 158 854 women after exclusion criteria, of whom 9757 (6.1%) were H2RA users. During median 8.2 years of follow-up, 376 H2RA users (4.9 events/1000 person-years) and 3206 nonusers (2.7 events/1000 person-years) developed incident HF. After multivariable adjustment, there was no association between H2RA use and HF in the primary analysis (hazard ratio, 1.07; 95% CI, 0.94-1.22;
=0.31) or in any of the sensitivity analyses. Conclusions Clinical H2RA use was not associated with incident HF among postmenopausal women. Future studies are needed to evaluate potential effect modification by sex, HF severity, or patterns of use on H2RA exposure and HF risk. Registration URL: https://www.clinicaltrials.gov; Unique identifier: NCT00000611.
Details
- Title: Subtitle
- Histamine H 2 Receptor Antagonists and Heart Failure Risk in Postmenopausal Women: The Women's Health Initiative
- Creators
- Sophia R Larson - University of WashingtonAlexi L Vasbinder - University of WashingtonKerryn W Reding - University of WashingtonPeter J Leary - University of WashingtonKelley R Branch - University of WashingtonAladdin H Shadyab - Human Longevity (United States)Karen C Johnson - University of Tennessee Health Science CenterBernhard Haring - Saarland UniversityRobert Wallace - University of IowaJoAnn E Manson - Brigham and Women's HospitalGarnet Anderson - Fred Hutch Cancer CenterRichard K Cheng - University of Washington
- Resource Type
- Journal article
- Publication Details
- Journal of the American Heart Association, Vol.11(5), p.e024270
- DOI
- 10.1161/JAHA.121.024270
- PMID
- 35191329
- PMCID
- PMC9075064
- NLM abbreviation
- J Am Heart Assoc
- ISSN
- 2047-9980
- eISSN
- 2047-9980
- Grant note
- HHSN268201600018C / NHLBI NIH HHS F31 NR018588 / NINR NIH HHS HHSN268201600003C / NHLBI NIH HHS HHSN268201600004C / NHLBI NIH HHS HHSN268201600002C / NHLBI NIH HHS HHSN268201600001C / NHLBI NIH HHS
- Language
- English
- Date published
- 03/2022
- Academic Unit
- Epidemiology; Injury Prevention Research Center; Internal Medicine
- Record Identifier
- 9984363628902771
Metrics
11 Record Views