Journal article
Histamine enhances HIV-1-induced modulation of dendritic cells to skew naïve T cell differentiation toward regulatory T cells
Virology (New York, N.Y.), Vol.442(2), pp.163-172
08/01/2013
DOI: 10.1016/j.virol.2013.04.009
PMID: 23652320
Abstract
Altered cytokine profiles and imbalanced frequencies of CD4+ T helper cell subsets are thought to be linked with HIV-1/AIDS pathogenesis, but the causes need to be further clarified. Histamine, a biogenic amine with many functions, shows enhancement in HIV-1 infected individuals, which are considered to link with disease progression, but is poorly understood. This study investigated histamine-assisted HIV-1 modulation of dendritic cell (DC) functions. Histamine and HIV-1 showed a synergistic role in induction of interleukin-10; histamine inhibited HIV-1-induced IL-12 production from MDDCs (monocyte-derived DCs); notably, histamine augmented HIV-1-induced MDDC functional polarization and skewed naïve T cell differentiation toward regulatory T cells (Tregs). The results indicate the novel role of histamine in HIV-1-induced DC functional regulation, which promoted Treg cell differentiation and up-regulated immunosuppressive factors. These findings help to bridge the correlation between elevated histamine and increased Treg cell frequency in HIV-1 infected individuals, and add to our understanding of HIV-1-induced immunosuppression.
Details
- Title: Subtitle
- Histamine enhances HIV-1-induced modulation of dendritic cells to skew naïve T cell differentiation toward regulatory T cells
- Creators
- Rong-Rong Zhai - Research Division of Clinical Pharmacology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaAi-Ping Jiang - Key Laboratory of Molecular Virology & Immunology, Institute Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, ChinaHai-Bo Wang - Key Laboratory of Molecular Virology & Immunology, Institute Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, ChinaLi Ma - Key Laboratory of Molecular Virology & Immunology, Institute Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, ChinaXiao-Xin Ren - Key Laboratory of Molecular Virology & Immunology, Institute Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, ChinaJin-Feng Jiang - Key Laboratory of Molecular Virology & Immunology, Institute Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, ChinaLi Wu - Department of Veterinary Biosciences, Center for Retrovirus Research, The Ohio State University, OH, USAJi-Fu Wei - Research Division of Clinical Pharmacology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaJian-Hua Wang - Key Laboratory of Molecular Virology & Immunology, Institute Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China
- Resource Type
- Journal article
- Publication Details
- Virology (New York, N.Y.), Vol.442(2), pp.163-172
- DOI
- 10.1016/j.virol.2013.04.009
- PMID
- 23652320
- NLM abbreviation
- Virology
- ISSN
- 0042-6822
- eISSN
- 1096-0341
- Publisher
- Elsevier Inc
- Grant note
- DOI: 10.13039/501100012166, name: National Basic Research Program of China (973 Program), award: 2012CB519004; name: 100 Talent Program of the Chinese Academy of Sciences (CAS), award: KSCX2-KW-BR-1; DOI: 10.13039/501100001809, name: Natural Science Foundation of China, award: 81171567; name: Shanghai Rising-Star Program (A type), award: 11QA1407700; name: Knowledge Innovation Program of CAS, award: KSCX2-YW-R210, KSCX2-EW-Q-2
- Language
- English
- Date published
- 08/01/2013
- Academic Unit
- Microbiology and Immunology
- Record Identifier
- 9984001222002771
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