Histidine phosphotransfer proteins in fungal two-component signal transduction pathways

Jan S Fassler; Ann H West

doi:10.1128/EC.00083-13

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Histidine phosphotransfer proteins in fungal two-component signal transduction pathways

Journal article

Open access

Peer reviewed

Histidine phosphotransfer proteins in fungal two-component signal transduction pathways

Jan S Fassler and Ann H West

Eukaryotic cell, Vol.12(8), pp.1052-1060

08/2013

DOI: 10.1128/EC.00083-13

PMCID: PMC3754533

PMID: 23771905

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Abstract

The histidine phosphotransfer (HPt) protein Ypd1 is an important participant in the Saccharomyces cerevisiae multistep two-component signal transduction pathway and, unlike the expanded histidine kinase gene family, is encoded by a single gene in nearly all model and pathogenic fungi. Ypd1 is essential for viability in both S. cerevisiae and in Cryptococcus neoformans. These and other aspects of Ypd1 biology, combined with the availability of structural and mutational data in S. cerevisiae, suggest that the essential interactions between Ypd1 and response regulator domains would be a good target for antifungal drug development. The goal of this minireview is to summarize the wealth of data on S. cerevisiae Ypd1 and to consider the potential benefits of conducting related studies in pathogenic fungi.

Protein Kinases - metabolism

Protein Structure, Tertiary

Amino Acid Sequence

Phosphorylation

Protein Kinases - genetics

Protein Structure, Secondary

Signal Transduction

Saccharomyces cerevisiae - genetics

Cryptococcus neoformans - genetics

Saccharomyces cerevisiae - pathogenicity

Intracellular Signaling Peptides and Proteins - metabolism

Histidine - metabolism

Saccharomyces cerevisiae Proteins - genetics

DNA-Binding Proteins - genetics

DNA-Binding Proteins - metabolism

Cryptococcus neoformans - pathogenicity

Antifungal Agents - metabolism

Saccharomyces cerevisiae Proteins - metabolism

Intracellular Signaling Peptides and Proteins - genetics

Details

Title: Subtitle: Histidine phosphotransfer proteins in fungal two-component signal transduction pathways
Creators: Jan S Fassler - Department of Biology, University of Iowa, Iowa City, Iowa, USA. jan-fassler@uiowa.edu
Ann H West
Resource Type: Journal article
Publication Details: Eukaryotic cell, Vol.12(8), pp.1052-1060
DOI: 10.1128/EC.00083-13
PMID: 23771905
PMCID: PMC3754533
NLM abbreviation: Eukaryot Cell
ISSN: 1535-9778
eISSN: 1535-9786
Publisher: American Society for Microbiology; United States
Grant note: R01 GM056719 / NIGMS NIH HHS
Language: English
Date published: 08/2013
Academic Unit: Biology
Record Identifier: 9983992077902771

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