Histologic and hemodynamic effects of endosaccular platinum coils for intracranial aneurysms

Alex M Barrocas; Colin P Derdeyn; Dewitte T Cross III; Christopher J Moran; Ralph G Dacey Jr

doi:10.1615/JLongTermEffMedImplants.v14.i3.70

Back

Histologic and hemodynamic effects of endosaccular platinum coils for intracranial aneurysms

Journal article

Peer reviewed

Histologic and hemodynamic effects of endosaccular platinum coils for intracranial aneurysms

Alex M Barrocas, Colin P Derdeyn, Dewitte T Cross III, Christopher J Moran and Ralph G Dacey Jr

Journal of long-term effects of medical implants, Vol.14(3), pp.225-242

2004

DOI: 10.1615/JLongTermEffMedImplants.v14.i3.70

PMID: 15301666

View Online

Abstract

Over the past 15 years, endosaccular platinum coil therapy for intracranial aneurysms has evolved from clinical pilot studies of investigational devices to common clinical practice. The mechanism by which these coils reduce the risk of aneurysm rupture-the primary goal of intracranial aneurysm treatment-is the focus of this review. Both histological mechanisms of scar formation and hemodynamic mechanisms of flow diversion may be involved. We will first review aneurysm epidemiology to provide the context and rationale for therapy for patients harboring intracranial aneurysms. Next, we will review the data for and theories of the pathophysiology of aneurysm formation, growth, and rupture, particularly as they relate to endovascular coil therapy. Histological and hemodynamic studies of coiled aneurysms in animals and humans will be reviewed. Finally, we will discuss emerging coil-based therapies, such as bioactive polymer coatings for platinum coils and the adjunctive use of stents.

Radiography

Intracranial Aneurysm - diagnostic imaging

Prognosis

Humans

Aneurysm, Ruptured - prevention & control

Male

Blood Vessel Prosthesis

Hemodynamics - physiology

Prosthesis Design

Balloon Occlusion - methods

Intracranial Aneurysm - therapy

Platinum

Swine

Female

Equipment Safety

Embolization, Therapeutic - methods

Disease Models, Animal

Severity of Illness Index

Balloon Occlusion - instrumentation

Rabbits

Risk Assessment

Intracranial Aneurysm - mortality

Magnetic Resonance Angiography

Treatment Outcome

Animals

Dogs

Survival Analysis

Sheep

Aneurysm, Ruptured - pathology

Intracranial Aneurysm - pathology

Details

Title: Subtitle: Histologic and hemodynamic effects of endosaccular platinum coils for intracranial aneurysms
Creators: Alex M Barrocas - Department of Neurology, Georgetown University, Washington DC, USA
Colin P Derdeyn
Dewitte T Cross III
Christopher J Moran
Ralph G Dacey Jr
Resource Type: Journal article
Publication Details: Journal of long-term effects of medical implants, Vol.14(3), pp.225-242
Publisher: United States
DOI: 10.1615/JLongTermEffMedImplants.v14.i3.70
PMID: 15301666
ISSN: 1050-6934
eISSN: 1940-4379
Language: English
Date published: 2004
Academic Unit: Neurology; Radiology; Iowa Neuroscience Institute; Neurosurgery
Record Identifier: 9984020999402771

Metrics

33 Record Views