Journal article
Histone Deacetylase Inhibitors Enhance Memory and Synaptic Plasticity via CREB: CBP-Dependent Transcriptional Activation
The Journal of neuroscience, Vol.27(23), pp.6128-6140
06/06/2007
DOI: 10.1523/JNEUROSCI.0296-07.2007
PMCID: PMC2925045
PMID: 17553985
Abstract
Histone deacetylase (HDAC) inhibitors increase histone acetylation and enhance both memory and synaptic plasticity. The current model for the action of HDAC inhibitors assumes that they alter gene expression globally and thus affect memory processes in a nonspecific manner. Here, we show that the enhancement of hippocampus-dependent memory and hippocampal synaptic plasticity by HDAC inhibitors is mediated by the transcription factor cAMP response element-binding protein (CREB) and the recruitment of the transcriptional coactivator and histone acetyltransferase CREB-binding protein (CBP) via the CREB-binding domain of CBP. Furthermore, we show that the HDAC inhibitor trichostatin A does not globally alter gene expression but instead increases the expression of specific genes during memory consolidation. Our results suggest that HDAC inhibitors enhance memory processes by the activation of key genes regulated by the CREB:CBP transcriptional complex.
Details
- Title: Subtitle
- Histone Deacetylase Inhibitors Enhance Memory and Synaptic Plasticity via CREB: CBP-Dependent Transcriptional Activation
- Creators
- Christopher G Vecsey - Neuroscience Graduate GroupJoshua D Hawk - Neuroscience Graduate GroupK. Matthew Lattal - Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon 97239Joel M Stein - Cell and Molecular Biology Graduate Group, University of Pennsylvania 19104Sara A Fabian - Department of Biology, andMichelle A Attner - Department of Biology, andSara M Cabrera - Department of Neurobiology and Behavior, Center for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, California 92697, andConor B McDonough - Neuroscience Graduate GroupPaul K Brindle - Department of Biochemistry, St. Jude Children's Research Hospital, Memphis, Tennessee 38105Ted Abel - Neuroscience Graduate GroupMarcelo A Wood - Department of Neurobiology and Behavior, Center for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, California 92697, and
- Resource Type
- Journal article
- Publication Details
- The Journal of neuroscience, Vol.27(23), pp.6128-6140
- Publisher
- Society for Neuroscience
- DOI
- 10.1523/JNEUROSCI.0296-07.2007
- PMID
- 17553985
- PMCID
- PMC2925045
- ISSN
- 0270-6474
- eISSN
- 1529-2401
- Language
- English
- Date published
- 06/06/2007
- Academic Unit
- Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
- Record Identifier
- 9984065736702771
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