Histone methylation is critical in monocyte to macrophage differentiation

Jennifer Bermick; Matthew Schaller; William Carson IV

doi:10.1111/febs.14074

Back

Histone methylation is critical in monocyte to macrophage differentiation

Journal article

Open access

Peer reviewed

Histone methylation is critical in monocyte to macrophage differentiation

Jennifer Bermick, Matthew Schaller and William Carson IV

The FEBS journal, Vol.284(9), pp.1306-1308

05/2017

DOI: 10.1111/febs.14074

PMID: 28463426

Files and links (1)

url

https://doi.org/10.1111/febs.14074View

Published (Version of record) Open Access

Abstract

Monocyte derived macrophages contribute to many human diseases, and a prescribed set of transcription factors control the differentiation of monocytes into macrophages. In this issue of The FEBS Journal, Jin and colleagues demonstrate that histone methylation changes in monocytes alter chromatin structure and ultimately direct the expression of numerous transcription factors crucial in this differentiation process.

Cell Differentiation

Animals

Epigenesis, Genetic

Gene Expression Regulation, Developmental

Histones - chemistry

Histones - metabolism

Humans

Macrophages - cytology

Macrophages - enzymology

Macrophages - metabolism

Methylation

Models, Biological

Monocytes - cytology

Monocytes - enzymology

Monocytes - metabolism

Promoter Regions, Genetic

Protein Processing, Post-Translational

Transcription Factors - genetics

Transcription Factors - metabolism

Details

Title: Subtitle: Histone methylation is critical in monocyte to macrophage differentiation
Creators: Jennifer Bermick - University of Michigan–Ann Arbor
Matthew Schaller - University of Michigan–Ann Arbor
William Carson IV - University of Michigan–Ann Arbor
Resource Type: Journal article
Publication Details: The FEBS journal, Vol.284(9), pp.1306-1308
DOI: 10.1111/febs.14074
PMID: 28463426
ISSN: 1742-464X
eISSN: 1742-4658
Language: English
Date published: 05/2017
Academic Unit: Stead Family Department of Pediatrics; Neonatology
Record Identifier: 9984353839702771

Metrics

23 Record Views

2 Times Cited - Web of Science

See more details