Journal article
History of Alcohol Use Disorders and Risk of Severe Cognitive Impairment: A 19-Year Prospective Cohort Study
The American journal of geriatric psychiatry, Vol.22(10), pp.1047-1054
10/01/2014
DOI: 10.1016/j.jagp.2014.06.001
PMCID: PMC4165640
PMID: 25091517
Abstract
Objective: To assess the effects of a history of alcohol use disorders (AUDs) on risk of severe cognitive and memory impairment in later life. Methods: We studied the association between history of AUDs and the onset of severe cognitive and memory impairment in 6,542 middle-aged adults born 1931 through 1941 who participated in the Health and Retirement Study, a prospective nationally representative U.S. cohort. Participants were assessed at 1992 baseline and follow-up cognitive assessments were conducted biannually from 1996 through 2010. History of AUDs was identified using the three-item modified CAGE questionnaire. Cognitive outcomes were assessed using the 35-item modified Telephone Interview for Cognitive Status at last follow-up with incident severe cognitive impairment defined as a score <= 8, and incident severe memory impairment defined as a score <= 1 on a 20-item memory subscale. Results: During up to 19 years of follow-up (mean: 16.7 years, standard deviation: 3.0, range: 3.5-19.1 years), 90 participants experienced severe cognitive impairment and 74 participants experienced severe memory impairment. History of AUDs more than doubled the odds of severe memory impairment (odds ratio [OR] = 2.21, 95% confidence interval [CI] = 1.27-3.85, t = 2.88, df = 52, p = 0.01). The association with severe cognitive impairment was statistically non-significant but in the same direction (OR = 1.80, 95% CI = 0.97-3.33, t = 1.92, df = 52, p = 0.06). Conclusion: Middle-aged adults with a history of AUDs have increased odds of developing severe memory impairment later in life. These results reinforce the need to consider the relationship between alcohol consumption and cognition from a multifactorial lifespan perspective.
Details
- Title: Subtitle
- History of Alcohol Use Disorders and Risk of Severe Cognitive Impairment: A 19-Year Prospective Cohort Study
- Creators
- Elzbieta Kuzma - National Institute for Health ResearchDavid J. Llewellyn - University of ExeterKenneth M. Langa - VA Center for Clinical Management ResearchRobert B. Wallace - University of IowaIain A. Lang - National Institute for Health Research
- Resource Type
- Journal article
- Publication Details
- The American journal of geriatric psychiatry, Vol.22(10), pp.1047-1054
- DOI
- 10.1016/j.jagp.2014.06.001
- PMID
- 25091517
- PMCID
- PMC4165640
- NLM abbreviation
- Am J Geriatr Psychiatry
- ISSN
- 1064-7481
- eISSN
- 1545-7214
- Publisher
- Elsevier
- Number of pages
- 8
- Grant note
- KMRF-2013-02-02 / National Institute for Health Research; National Institute for Health Research (NIHR) James Tudor Foundation Halpin Trust Mary Kinross Charitable Trust P30ES005605 / NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) National Institute for Health Research Knowledge Mobilisation Research Fellowship NIRG-11-200737 / Alzheimer Association; Alzheimer's Association; BrightFocus Foundation National Institute for Health Research (NIHR) Collaboration for Leadership in Applied Health Research and Care (CLAHRC) for the South West Peninsula Norman Family Charitable Trust National Institute for Health Research; National Institute for Health Research (NIHR) U01AG09740 / National Institute on Aging (NIA); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) U01AG009740 / NATIONAL INSTITUTE ON AGING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA)
- Language
- English
- Date published
- 10/01/2014
- Academic Unit
- Epidemiology; Injury Prevention Research Center; Internal Medicine
- Record Identifier
- 9984363640502771
Metrics
14 Record Views