History of urinary tract infection and risk of renal cell carcinoma

Alexander S Parker; James R Cerhan; Charles F Lynch; Bradley C Leibovich; Kenneth P Cantor

doi:10.1093/aje/kwh014

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History of urinary tract infection and risk of renal cell carcinoma

Journal article

Open access

Peer reviewed

History of urinary tract infection and risk of renal cell carcinoma

Alexander S Parker, James R Cerhan, Charles F Lynch, Bradley C Leibovich and Kenneth P Cantor

American journal of epidemiology, Vol.159(1), pp.42-48

01/01/2004

DOI: 10.1093/aje/kwh014

PMID: 14693658

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Abstract

Limited data exist regarding whether a history of urinary tract infection (UTI) increases risk of developing renal cell carcinoma (RCC). Furthermore, it is unclear whether any association of RCC with a history of UTIs is modified by known risk factors for RCC (i.e., smoking, obesity). The authors report data from a 1986-1989 population-based case-control study in Iowa. RCC cases (233 males, 139 females) were identified through the Iowa Cancer Registry; controls (1,497 males, 751 females) were randomly selected from the general population, frequency matched on age and sex. Subjects provided detailed information on demographic, anthropometric, lifestyle, dietary, and medical history risk factors. In age-adjusted analysis, risk increased for subjects who self-reported a history of physician-diagnosed kidney or bladder infection (odds ratio (OR) = 1.9, 95% confidence interval (CI): 1.5, 2.5) compared with those reporting no such history. Both sex and smoking status modified the risk of RCC associated with a history of UTI, with the strongest risk reported for males (OR = 2.7, 95% CI: 1.9, 3.8) and current smokers (OR = 4.3, 95% CI: 2.7, 6.7). The strongest risk was reported for male current smokers with a history of UTI (OR = 9.7, 95% CI: 5.0, 18.1). Multivariate adjustment for anthropometric, lifestyle, and dietary factors did not alter these findings. Results suggest a positive association of UTI history with RCC development, with elevated risks most notable for males with a history of smoking.

Life Style

Kidney Neoplasms - epidemiology

Humans

Middle Aged

Risk Factors

Male

Urinary Tract Infections - complications

Case-Control Studies

Carcinoma, Renal Cell - epidemiology

Diet

Kidney Neoplasms - etiology

Sex Factors

Aged, 80 and over

Adult

Female

Iowa - epidemiology

Registries

Surveys and Questionnaires

Aged

Carcinoma, Renal Cell - etiology

Smoking

Details

Title: Subtitle: History of urinary tract infection and risk of renal cell carcinoma
Creators: Alexander S Parker - Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA. parker.alexanader@mayo.edu
James R Cerhan
Charles F Lynch
Bradley C Leibovich
Kenneth P Cantor
Resource Type: Journal article
Publication Details: American journal of epidemiology, Vol.159(1), pp.42-48
Publisher: United States
DOI: 10.1093/aje/kwh014
PMID: 14693658
ISSN: 0002-9262
eISSN: 1476-6256
Language: English
Date published: 01/01/2004
Academic Unit: Epidemiology
Record Identifier: 9983996200002771

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