Journal article
Hitting the hidden: arming the immune system for the next zoonotic coronavirus spillover
The Journal of clinical investigation, Vol.136(6), e203781
03/16/2026
DOI: 10.1172/JCI203781
PMCID: PMC12987610
PMID: 41837282
Abstract
Coronaviruses, both known and yet to emerge, pose persistent zoonotic and pandemic threats. While current parenteral COVID-19 mRNA vaccines effectively mitigate severe disease caused by SARS-CoV-2, they primarily elicit systemic immunity restricted to specific variants within clade 1b of the sarbecovirus subgenus and provide limited mucosal protection. Addressing these shortcomings, Cheang et al. developed a DC-targeting intranasal booster vaccine that induces robust and durable mucosal and systemic immunity across sarbecovirus clades 1a and 1b. This study highlights a promising strategy for pan-sarbecovirus vaccines by leveraging mucosal immune induction to prevent viral transmission and enhance pandemic preparedness.
Details
- Title: Subtitle
- Hitting the hidden: arming the immune system for the next zoonotic coronavirus spillover
- Creators
- Charlie Fricke - Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa, USAStanley Perlman - Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa, USA
- Resource Type
- Journal article
- Publication Details
- The Journal of clinical investigation, Vol.136(6), e203781
- DOI
- 10.1172/JCI203781
- PMID
- 41837282
- PMCID
- PMC12987610
- NLM abbreviation
- J Clin Invest
- ISSN
- 0021-9738
- eISSN
- 1558-8238
- Publisher
- American Society for Clinical Investigation
- Grant note
- NIH: R01 AI129269 Eli Lilly and Company
This work is the result of NIH funding, in whole or in part, and is subject to the NIH Public Access Policy. Through acceptance of this federal funding, the NIH has been given a right to make the work publicly available in PubMed Central.NIH grant R01 AI129269.Aegis COVID-19 study, administered through the Indiana University (IU) School of Public Health-Bloomington and supported by multiple anonymous donations to the IU Foundation and by Eli Lilly and Company.
- Language
- English
- Date published
- 03/16/2026
- Academic Unit
- Microbiology and Immunology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Infectious Disease (Pediatrics)
- Record Identifier
- 9985147195602771
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