Hodgkin Lymphoma-Associated Superior Vena Cava Syndrome: A Case Report and Review of the Literature

Ruoning Ni; Mahmoud Amr; Abhishek Kalla

doi:10.12659/AJCR.929437

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Journal article

Hodgkin Lymphoma-Associated Superior Vena Cava Syndrome: A Case Report and Review of the Literature

Ruoning Ni, Mahmoud Amr and Abhishek Kalla

The American journal of case reports, Vol.22(1), pp.e929437-e929437-9

04/10/2021

DOI: 10.12659/AJCR.929437

PMCID: PMC8045558

PMID: 33837173

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Abstract

BACKGROUND Hodgkin lymphoma (HL) is a relatively rare etiology of superior vena cava (SVC) syndrome, with only 24 cases reported in the literature. The characteristics, management, and prognosis of HL-associated SVC syndrome remain unclear. This case report describes nodular sclerosis classical HL and the associated clinical manifestations presenting as SVC syndrome in a middle-aged patient, and it summarizes the characteristics of HL-associated SVC syndrome. CASE REPORT In this case report, we present a 53-year-old Hispanic man with progressively worsening dyspnea, dry cough, facial and neck edema, and dysphagia. SVC syndrome was diagnosed, and pathology revealed nodular sclerosis classical HL. The patient was treated with doxorubicin, bleomycin, vinblastine, and dacarbazine. SVC syndrome improved, and repeated imaging showed that the lymphoma had decreased in size and had become metabolically inactive. CONCLUSIONS We reviewed the characteristics, management, and prognosis of HL-associated SVC syndrome, which may indicate more advanced and recurrent progression in patients with HL. This possibility suggests that physicians should provide urgent diagnosis and closer follow-up, and more aggressive therapies may be needed because of the high risk of recurrence. Therapy may induce late-onset SVC syndrome in patients with HL.

Doxorubicin - therapeutic use

Hodgkin Disease - complications

Hodgkin Disease - diagnosis

Humans

Male

Middle Aged

Neoplasm Recurrence, Local

Superior Vena Cava Syndrome - diagnosis

Superior Vena Cava Syndrome - etiology

Vena Cava, Superior

Details

Title: Subtitle: Hodgkin Lymphoma-Associated Superior Vena Cava Syndrome: A Case Report and Review of the Literature
Creators: Ruoning Ni - Saint Agnes Hospital
Mahmoud Amr - Saint Agnes Hospital
Abhishek Kalla - Saint Agnes Hospital
Resource Type: Journal article
Publication Details: The American journal of case reports, Vol.22(1), pp.e929437-e929437-9
DOI: 10.12659/AJCR.929437
PMID: 33837173
PMCID: PMC8045558
NLM abbreviation: Am J Case Rep
ISSN: 1941-5923
eISSN: 1941-5923
Language: English
Date published: 04/10/2021
Academic Unit: Internal Medicine
Record Identifier: 9984946629202771

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