Homeostatic control of Drosophila neuromuscular junction function

C. Andrew Frank; Thomas D James; Martin Müller

doi:10.1002/syn.22133

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Homeostatic control of Drosophila neuromuscular junction function

Journal article

Open access

Peer reviewed

Homeostatic control of Drosophila neuromuscular junction function

C. Andrew Frank, Thomas D James and Martin Müller

Synapse (New York, N.Y.), Vol.74(1), pp.e22133-n/a

01/2020

DOI: 10.1002/syn.22133

PMCID: PMC6817395

PMID: 31556149

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https://doi.org/10.1002/syn.22133View

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Abstract

The ability to adapt to changing internal and external conditions is a key feature of biological systems. Homeostasis refers to a regulatory process that stabilizes dynamic systems to counteract perturbations. In the nervous system, homeostatic mechanisms control neuronal excitability, neurotransmitter release, neurotransmitter receptors, and neural circuit function. The neuromuscular junction (NMJ) of Drosophila melanogaster has provided a wealth of molecular information about how synapses implement homeostatic forms of synaptic plasticity, with a focus on the transsynaptic, homeostatic modulation of neurotransmitter release. This review examines some of the recent findings from the Drosophila NMJ and highlights questions the field will ponder in coming years. At the larval Drosophila neuromuscular junction (NMJ), neurotransmitter receptor (blue) perturbation in the muscle cell (gray cylinder) enhances neurotransmitter release (green, “Presynaptic homeostatic potentiation”, PHP) from the motor neuron. This review summarizes recent updates on this evolutionarily conserved form of transsynaptic plasticity.

homeostatic plasticity

synaptic plasticity

presynaptic mechanisms

neurotransmitter release

transsynaptic signalling

Details

Title: Subtitle: Homeostatic control of Drosophila neuromuscular junction function
Creators: C. Andrew Frank - University of Iowa
Thomas D James - University of Iowa
Martin Müller - Neuroscience Center Zurich
Resource Type: Journal article
Publication Details: Synapse (New York, N.Y.), Vol.74(1), pp.e22133-n/a
DOI: 10.1002/syn.22133
PMID: 31556149
PMCID: PMC6817395
NLM abbreviation: Synapse
ISSN: 0887-4476
eISSN: 1098-2396
Number of pages: 13
Grant note: Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (PP00P3_144816) H2020 European Research Council (679881) National Institute of Neurological Disorders and Stroke (R01NS085164; T32NS007421) National Science Foundation (1557792)
Language: English
Date published: 01/2020
Academic Unit: Anatomy and Cell Biology; Iowa Neuroscience Institute; Biology; Neuroscience and Pharmacology
Record Identifier: 9984070287102771

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