Homing in on the specific phenotype(s) of central respiratory chemoreceptors

G B Richerson; W Wang; M R Hodges; C I Dohle; A Diez-Sampedro

doi:10.1111/j.1469-445X.2005.tb00002.x

Back

Homing in on the specific phenotype(s) of central respiratory chemoreceptors

Journal article

Open access

Homing in on the specific phenotype(s) of central respiratory chemoreceptors

G B Richerson, W Wang, M R Hodges, C I Dohle and A Diez-Sampedro

Experimental physiology, Vol.90(3), pp.259-266

05/2005

DOI: 10.1111/j.1469-445X.2005.tb00002.x

PMID: 15728134

Files and links (1)

url

https://doi.org/10.1111/j.1469-445X.2005.tb00002.xView

Published (Version of record) Open Access

Abstract

To some it may seem that we now know less about respiratory chemoreception than we did 20 years ago. Back then, it was widely accepted that the central respiratory chemoreceptors (CRCs) were located exclusively on or near the surface of the ventrolateral medulla (VLMS). Now, instead, it is generally believed that there are widespread sites of chemoreception, and there is little agreement on when and how each of these sites is involved in respiratory control. However, those in the field know that this actually is progress, primarily because we have gone from simply identifying candidate regions, to identifying specific neuronal subtypes that may be the sensors. In this invited review, we have been asked to discuss some of the current controversies in the field. First, we define the minimal requirements for a cell to be a CRC, and what assumptions can not be made without more data. Then we review the evidence that two neuronal subtypes, serotonergic neurones of the midline raphe and glutamatergic neurones of the retrotrapezoid nucleus, are chemoreceptors. There is evidence supporting a role in respiratory chemoreception for both types of neurone, as well as the other candidates, but there is also information that is missing. Future work will need to focus on which of the candidates are indeed chemoreceptors, what percentage of the overall response each one contributes, and how this percentage varies under different conditions.

Phenotype

Lung - innervation

Animals

Humans

Serotonin - metabolism

Chemoreceptor Cells - physiology

Glutamic Acid - metabolism

Lung - physiology

Respiration

Carbon Dioxide - blood

Medulla Oblongata - physiology

Details

Title: Subtitle: Homing in on the specific phenotype(s) of central respiratory chemoreceptors
Creators: G B Richerson - Department of Neurology, Yale University School of Medicine, New Haven, CT 06520-8018, USA. george.richerson@yale.edu
W Wang
M R Hodges
C I Dohle
A Diez-Sampedro
Resource Type: Journal article
Publication Details: Experimental physiology, Vol.90(3), pp.259-266
Publisher: England
DOI: 10.1111/j.1469-445X.2005.tb00002.x
PMID: 15728134
ISSN: 0958-0670
eISSN: 1469-445X
Grant note: NHLBI HL52539 / NHLBI NIH HHS NICHD HD36379 / NICHD NIH HHS
Language: English
Date published: 05/2005
Academic Unit: Neurology; Molecular Physiology and Biophysics; Iowa Neuroscience Institute; Neurosurgery
Record Identifier: 9984014021402771

Metrics

22 Record Views

103 Times Cited - Web of Science