Journal article
Homocysteine Metabolism in Children with Idiopathic Nephrotic Syndrome
Clinical and translational science, Vol.7(2), pp.132-136
04/01/2014
DOI: 10.1111/cts.12145
PMCID: PMC5350952
PMID: 24456587
Abstract
BackgroundHomocysteine metabolism is altered in children with idiopathic nephrotic syndrome. Hyperhomocysteinemia is a risk factor of early atherosclerosis and glomerulosclerosis and may occur at time of first occurrence of idiopathic nephrotic syndrome.
MethodsThirty children with first episode of idiopathic nephrotic syndrome (FENS) aged 1-16 years along with 30 age- and sex-matched healthy controls were enrolled in this study. Homocysteine and cysteine were measured with HPLC; vitamin B-12 and folic acid were measured with electro-chemilumiscence immunoassay. Primary outcome measure was plasma homocysteine level in children with FENS and in controls. Secondary outcome measures were (1) plasma and urine homocysteine and cysteine levels in children with FENS at 12 weeks and 1 year (remission) and (2) plasma and urine levels of vitamin B-12 and folic acid in children with FENS, at 12 weeks and 1 year (remission).
ResultsPlasma homocysteine and cysteine levels were comparable to controls in children with FENS, at 12 weeks and 1-year remission. Plasma levels of vitamin B12 and folic acid were significantly decreased compared to controls in FENS due to increased urinary excretion, which normalize during remission at 12 weeks and 1 year. Urinary homocysteine and cysteine levels were significantly raised in FENS compared to controls and continued to be raised even at 12-week and 1-year remission.
ConclusionHomocysteine metabolism is deranged in children with FENS. Renal effects of long-term raised urinary homocysteine levels need to be studied.
Details
- Title: Subtitle
- Homocysteine Metabolism in Children with Idiopathic Nephrotic Syndrome
- Creators
- Mohan Kundal - Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia HospitalAbhijeet Saha - Institute of Genomics and Integrative BiologyN. K. Dubey - Govind Ballabh Pant HospitalKanika Kapoor - AIIMS, New DelhiTrayambak Basak - Institute of Genomics and Integrative BiologyGaurav Bhardwaj - CSIR Inst Genom & Integrat Biol, New Delhi, IndiaVinay Singh Tanwar - Institute of Genomics and Integrative BiologyShantanu Sengupta - Institute of Genomics and Integrative BiologyVinita Batra - Govind Ballabh Pant HospitalAshish Dutt Upadhayay - All India Institute of Medical SciencesAjay Bhatt - Institute of Genomics and Integrative Biology
- Resource Type
- Journal article
- Publication Details
- Clinical and translational science, Vol.7(2), pp.132-136
- DOI
- 10.1111/cts.12145
- PMID
- 24456587
- PMCID
- PMC5350952
- NLM abbreviation
- Clin Transl Sci
- ISSN
- 1752-8054
- eISSN
- 1752-8062
- Publisher
- Wiley
- Number of pages
- 5
- Grant note
- CSIR; Council of Scientific & Industrial Research (CSIR) - India
- Language
- English
- Date published
- 04/01/2014
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984359767102771
Metrics
18 Record Views