Honokiol, a natural plant product, inhibits inflammatory signals and alleviates inflammatory arthritis

Melissa E Munroe; Jack L Arbiser; Gail A Bishop

doi:10.4049/jimmunol.179.2.753

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Honokiol, a natural plant product, inhibits inflammatory signals and alleviates inflammatory arthritis

Journal article

Peer reviewed

Honokiol, a natural plant product, inhibits inflammatory signals and alleviates inflammatory arthritis

Melissa E Munroe, Jack L Arbiser and Gail A Bishop

The Journal of immunology (1950), Vol.179(2), pp.753-763

07/15/2007

DOI: 10.4049/jimmunol.179.2.753

PMID: 17617564

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Abstract

Honokiol (HNK), a phenolic compound isolated and purified from magnolia, has been found to have a number of pharmacologic benefits, including anti-angiogenic and anti-inflammatory properties. HNK has long been used in traditional Asian medicine without toxic side effects. We and others have extensively studied signaling to B cells by CD40 and its Epstein Barr viral mimic, latent membrane protein 1 (LMP1), which has been implicated in exacerbation of chronic autoimmune disease. We asked whether HNK could inhibit CD40 and LMP1 inflammatory signaling mechanisms. In vivo, HNK stabilized the severity of symptomatic collagen-induced arthritis in both CD40-LMP1 transgenic mice and their congenic C57BL/6 counterparts. Ex vivo studies, including collagen-specific serum Ab and Ag recall responses, as well as CD40 or LMP1-mediated activation of splenic B cells, supported the anti-inflammatory effects of HNK. In mouse B cell lines expressing the human CD40-LMP1 chimeric receptor, CD40- and LMP1-mediated NF-kappaB and AP-1 activation were abrogated in a dose-dependent manner, with a concomitant decrease in TNF-alpha and IL-6. These promising findings suggest that the nontoxic anti-inflammatory properties of HNK could be valuable for blocking the autoimmune response.

Cell Line

Inflammation - pathology

Transcription Factor AP-1 - drug effects

Arthritis, Experimental - drug therapy

Enzyme-Linked Immunosorbent Assay

Humans

Mice, Transgenic

Biphenyl Compounds - therapeutic use

Lignans - therapeutic use

Anti-Allergic Agents - therapeutic use

Arthritis, Experimental - pathology

Dose-Response Relationship, Drug

B-Lymphocytes - drug effects

Animals

TNF Receptor-Associated Factor 2 - drug effects

Inflammation - drug therapy

Plant Preparations - therapeutic use

Female

Mice

CD40 Antigens - drug effects

Phytotherapy

Magnolia - immunology

NF-kappa B - drug effects

Details

Title: Subtitle: Honokiol, a natural plant product, inhibits inflammatory signals and alleviates inflammatory arthritis
Creators: Melissa E Munroe - Department of Microbiology, University of Iowa, IA 52242, USA
Jack L Arbiser
Gail A Bishop
Resource Type: Journal article
Publication Details: The Journal of immunology (1950), Vol.179(2), pp.753-763
DOI: 10.4049/jimmunol.179.2.753
PMID: 17617564
NLM abbreviation: J Immunol
ISSN: 0022-1767
eISSN: 1550-6606
Publisher: United States
Language: English
Date published: 07/15/2007
Academic Unit: Microbiology and Immunology; President
Record Identifier: 9984002378402771

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