Journal article
Hormone Receptors in Serous Ovarian Carcinoma: Prognosis, Pathogenesis, and Treatment Considerations
Clinical Medicine Insights. Oncology, Vol.10(10), pp.17-25
01/2016
DOI: 10.4137/CMO.S32813
PMCID: PMC4814131
PMID: 27053923
Abstract
A few breakthroughs have been accomplished for the treatment of ovarian cancer, the most deadly gynecologic carcinoma, in the current era of targeted oncologic treatment. The estrogen receptor was the first target of such treatments with the introduction of tamoxifen four decades ago in breast cancer therapeutics. Attempts to duplicate the success of hormonal therapies in ovarian cancer met with mixed results, which may be due to an inferior degree of hormone dependency in this cancer. Alternatively, this may be due to the failure to clearly identify the subsets of ovarian cancer with hormone sensitivity. This article reviews the expression of hormone receptors by ovarian cancer cells, the prognostic value of these expressions, and their predictive capacity for response to hormonal agents. The possible ways ahead are briefly discussed.
Details
- Title: Subtitle
- Hormone Receptors in Serous Ovarian Carcinoma: Prognosis, Pathogenesis, and Treatment Considerations
- Creators
- Ioannis A. Voutsadakis - Sault Area Hosp, Div Med Oncol, Dept Internal Med, Sault Ste Marie, ON, Canada
- Resource Type
- Journal article
- Publication Details
- Clinical Medicine Insights. Oncology, Vol.10(10), pp.17-25
- DOI
- 10.4137/CMO.S32813
- PMID
- 27053923
- PMCID
- PMC4814131
- NLM abbreviation
- Clin Med Insights Oncol
- ISSN
- 1179-5549
- eISSN
- 1179-5549
- Publisher
- Sage
- Number of pages
- 9
- Language
- English
- Date published
- 01/2016
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984806599802771
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