Journal article
Hormone therapy and age-related macular degeneration : The Women's health initiative sight exam study
Archives of ophthalmology (1960), Vol.124(7), pp.988-992
2006
DOI: 10.1001/archopht.124.7.988
PMID: 16832022
Abstract
Objective: To determine the effectiveness of treatment with conjugated equine estrogens (CEE) or with CEE combined with progestin (CEE6 + P) on age-related macular degeneration (AMD). Methods: In an ancillary study to the Women's Health Initiative clinical trial of hormone therapy, 4262 women 65 years and older underwent fundus photography for the determination of AMD. Participants were recruited from April 2000 to June 2002 at 21 clinical sites an average of 5 years after randomization. Participants were randomized to treatment with CEE, CEE + P, or placebo. Participants had been treated for an average of 5 years at the ophthalmic evaluation for AMD. Results: The overall prevalence of any AMD was 21.0%. No association was found between CEE + P (odds ratio [OR], 0.91; 95% confidence interval [CI], 0.75-1.11) or CEE alone (OR, 0.98; 95% CI, 0.78-1.25) and early-stage AMD. The CEE + P was associated with a reduced risk of soft drusen (OR, 0.83; 95% CI, 0.68-1.00) after adjustment for covariates and with a reduced risk of neovascular AMD (OR, 0.29; 95% CI, 0.09-0.92). Conclusions: Treatment with CEE alone or CEE + P does not affect early- or late-stage AMD. Treatment with CEE + P may reduce the risk of soft drusen or neovascular AMD. ©2006 American Medical Association. All rights reserved.
Details
- Title: Subtitle
- Hormone therapy and age-related macular degeneration : The Women's health initiative sight exam study
- Creators
- Mary N Haan - University of MichiganRonald Klein - University of Wisconsin–MadisonBarbara E Klein - University of Wisconsin–MadisonYINGZI Deng - University of MichiganLynn K Blythe - University of MichiganJohanna M Seddon - Harvard Medical SchoolDavid C Musch - University of MichiganLewis H Kuller - University of PittsburghLeslie G Hyman - Department of Preventive Medicine, State University of New York at Stony Brook, United StatesRobert B Wallace - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Archives of ophthalmology (1960), Vol.124(7), pp.988-992
- DOI
- 10.1001/archopht.124.7.988
- PMID
- 16832022
- NLM abbreviation
- Arch Ophthalmol
- ISSN
- 0003-9950
- eISSN
- 1538-3601
- Publisher
- American Medical Association
- Language
- English
- Date published
- 2006
- Academic Unit
- Epidemiology; Injury Prevention Research Center; Internal Medicine
- Record Identifier
- 9984364403102771
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