Hospital specificity, region specificity, and fluconazole resistance of Candida albicans bloodstream isolates

M A Pfaller; S R Lockhart; C Pujol; J A Swails-Wenger; S A Messer; M B Edmond; R N Jones; R P Wenzel; D R Soll

doi:10.1128/JCM.36.6.1518-1529.1998

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Hospital specificity, region specificity, and fluconazole resistance of Candida albicans bloodstream isolates

Journal article

Open access

Peer reviewed

Hospital specificity, region specificity, and fluconazole resistance of Candida albicans bloodstream isolates

M A Pfaller, S R Lockhart, C Pujol, J A Swails-Wenger, S A Messer, M B Edmond, R N Jones, R P Wenzel and D R Soll

Journal of clinical microbiology, Vol.36(6), pp.1518-1529

06/1998

DOI: 10.1128/JCM.36.6.1518-1529.1998

PMCID: PMC104870

PMID: 9620370

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Abstract

In a survey of bloodstream infection (BSI) isolates across the continental United States, 162 Candida albicans isolates were fingerprinted with the species-specific probe Ca3 and the patterns were analyzed for relatedness with a computer-assisted system. The results demonstrate that particular BSI strains are more highly concentrated in particular geographic locales and that established BSI strains are endemic in some, but not all, hospitals in the study and undergo microevolution in hospital settings. The results, however, indicate no close genetic relationship among fluconazole-resistant BSI isolates in the collection, either from the same geographic locale or the same hospital. This study represents the first of three fingerprinting studies designed to analyze the origin, genetic relatedness, and drug resistance of Candida isolates responsible for BSI.

Antifungal Agents - pharmacology

United States - epidemiology

Fluconazole - pharmacology

DNA, Fungal - analysis

Species Specificity

DNA Fingerprinting

Humans

Candidiasis - epidemiology

Candida albicans - classification

Phylogeny

Candidiasis - microbiology

Fungemia - microbiology

Candida albicans - genetics

Microbial Sensitivity Tests

Drug Resistance, Microbial

Candida albicans - drug effects

Hospitals

Candida albicans - isolation & purification

Cross Infection - microbiology

Fungemia - epidemiology

Cross Infection - epidemiology

Details

Title: Subtitle: Hospital specificity, region specificity, and fluconazole resistance of Candida albicans bloodstream isolates
Creators: M A Pfaller - University of Iowa, University of Iowa Health Care
S R Lockhart
C Pujol
J A Swails-Wenger
S A Messer
M B Edmond
R N Jones
R P Wenzel
D R Soll
Resource Type: Journal article
Publication Details: Journal of clinical microbiology, Vol.36(6), pp.1518-1529
DOI: 10.1128/JCM.36.6.1518-1529.1998
PMID: 9620370
PMCID: PMC104870
NLM abbreviation: J Clin Microbiol
ISSN: 0095-1137
eISSN: 1098-660X
Publisher: United States
Grant note: T32 AG000214 / NIA NIH HHS DE1058 / NIDCR NIH HHS AI2392 / NIAID NIH HHS Z01 AG000214 / Intramural NIH HHS
Language: English
Date published: 06/1998
Academic Unit: Epidemiology; Pathology; Internal Medicine
Record Identifier: 9983905646902771

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