Hospitalizations for Invasive Pneumococcal Disease Among HIV-1-Infected Adolescents and Adults in the United States in the Era of Highly Active Antiretroviral Therapy and the Conjugate Pneumococcal Vaccine

Athena P. Kourtis; Sascha Ellington; Pooja Bansil; Denise J. Jamieson; Samuel F. Posner

doi:10.1097/QAI.0b013e3181e8ed15

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Hospitalizations for Invasive Pneumococcal Disease Among HIV-1-Infected Adolescents and Adults in the United States in the Era of Highly Active Antiretroviral Therapy and the Conjugate Pneumococcal Vaccine

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Hospitalizations for Invasive Pneumococcal Disease Among HIV-1-Infected Adolescents and Adults in the United States in the Era of Highly Active Antiretroviral Therapy and the Conjugate Pneumococcal Vaccine

Athena P. Kourtis, Sascha Ellington, Pooja Bansil, Denise J. Jamieson and Samuel F. Posner

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, Vol.55(1), pp.128-131

09/01/2010

DOI: 10.1097/QAI.0b013e3181e8ed15

PMID: 20622675

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Abstract

We describe hospitalization trends of invasive pneumococcal disease (IPD) among HIV-infected adolescents and adults since the introduction of highly active antiretroviral therapy (HAART) and the 7-valent pneumococcal conjugate vaccine (PCV7) in the United States, using the nation-wide inpatient sample. We estimated national trends of IPD hospitalizations during 3 periods: 1994-1995 (pre-HAART/pre-PCV7); 1998-1999 (HAART/pre-PCV7); and 2004-2005 (HAART/early PCV7). The number of IPD hospitalizations among HIV-infected individuals declined 49.2% between 1994/1995 and 2004/2005. Compared with 1994-1995, the adjusted odds ratio for IPD hospitalizations of HIV-infected adolescents and adults in the United States during 2004-2005 was 0.64 (95% confidence interval: 0.54 to 0.77). The decrease was observed after introduction of the PCV7.

Immunology

Infectious Diseases

Life Sciences & Biomedicine

Science & Technology

Details

Title: Subtitle: Hospitalizations for Invasive Pneumococcal Disease Among HIV-1-Infected Adolescents and Adults in the United States in the Era of Highly Active Antiretroviral Therapy and the Conjugate Pneumococcal Vaccine
Creators: Athena P. Kourtis - Centers for Disease Control and Prevention
Sascha Ellington - Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA
Pooja Bansil - CONRAD, Atlanta, GA USA
Denise J. Jamieson - Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA
Samuel F. Posner - Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA
Resource Type: Journal article
Publication Details: JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, Vol.55(1), pp.128-131
DOI: 10.1097/QAI.0b013e3181e8ed15
PMID: 20622675
NLM abbreviation: J Acquir Immune Defic Syndr
ISSN: 1525-4135
eISSN: 2331-6993
Publisher: Lippincott Williams & Wilkins
Number of pages: 4
Language: English
Date published: 09/01/2010
Academic Unit: Obstetrics and Gynecology; VPMA - Administration
Record Identifier: 9984446408402771

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