Journal article
Host Factors and Cancer Progression: Biobehavioral Signaling Pathways and Interventions
Journal of clinical oncology, Vol.28(26), pp.4094-4099
09/10/2010
DOI: 10.1200/JCO.2009.26.9357
PMCID: PMC2940426
PMID: 20644093
Abstract
Whereas evidence for the role of psychosocial factors in cancer initiation has been equivocal, support continues to grow for links between psychological factors such as stress, depression, and social isolation and progression of cancer. In vitro, in vivo, and clinical studies show that stress- related processes can impact pathways implicated in cancer progression, including immuno-regulation, angiogenesis, and invasion. Contributions of systemic factors, such as stress hormones to the crosstalk between tumor and stromal cells, appear to be critical in modulating downstream signaling pathways with important implications for disease progression. Inflammatory pathways may also be implicated in fatigue and other factors related to quality of life. Although substantial evidence supports a positive effect of psychosocial interventions on quality of life in cancer, the clinical evidence for efficacy of stress-modulating psychosocial interventions in slowing cancer progression remains inconclusive, and the biobehavioral mechanisms that might explain such effects are still being established. This article reviews research findings to date and outlines future avenues of research in this area.
Details
- Title: Subtitle
- Host Factors and Cancer Progression: Biobehavioral Signaling Pathways and Interventions
- Creators
- Susan K Lutgendorf - From the Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA; University of Texas M. D. Anderson Comprehensive Cancer Center, Houston, TX; and the Sylvester Cancer Center, University of Miami, Miami, FLAnil K Sood - From the Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA; University of Texas M. D. Anderson Comprehensive Cancer Center, Houston, TX; and the Sylvester Cancer Center, University of Miami, Miami, FLMichael H Antoni - From the Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA; University of Texas M. D. Anderson Comprehensive Cancer Center, Houston, TX; and the Sylvester Cancer Center, University of Miami, Miami, FL
- Resource Type
- Journal article
- Publication Details
- Journal of clinical oncology, Vol.28(26), pp.4094-4099
- DOI
- 10.1200/JCO.2009.26.9357
- PMID
- 20644093
- PMCID
- PMC2940426
- NLM abbreviation
- J Clin Oncol
- ISSN
- 0732-183X
- eISSN
- 1527-7755
- Publisher
- American Society of Clinical Oncology
- Grant note
- CA110793; CA109298; R21CA88293; R01CA104825; CA102515; R01CA140933; 2R01CA064710-10A1 / National Institutes of Health
- Language
- English
- Date published
- 09/10/2010
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute; Obstetrics and Gynecology; Urology
- Record Identifier
- 9984065880202771
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