Journal article
Host Genetic Factors and Vaccine-Induced Immunity to HBV Infection: Haplotype Analysis
PloS one, Vol.5(8), pp.e12273-e12273
2010
DOI: 10.1371/journal.pone.0012273
PMCID: PMC2923624
PMID: 20806065
Abstract
Hepatitis B virus (HBV) infection remains a significant health burden world-wide, although vaccines help decrease this problem. We previously identified associations of single nucleotide polymorphisms in several candidate genes with vaccine-induced peak antibody level (anti-HBs), which is predictive of long-term vaccine efficacy and protection against infection and persistent carriage; here we report on a haplotype-based analysis. A total of 688 SNPs from 117 genes were examined for a two, three and four sliding window haplotype analysis in a Gambian cohort. Analysis was performed on 197 unrelated individuals, 454 individuals from 174 families, and the combined sample (N = 651). Global and individual haplotype association tests were carried out (adjusted for covariates), employing peak anti-HBs level as outcome. Five genes (
CD44, CD58, CDC42, IL19
and
IL1R1
) had at least one significant haplotype in the unrelated or family analysis as well as the combined analysis. Previous single locus results were confirmed for
CD44
(combined global p = 9.1×10
−5
for rs353644-rs353630-rs7937602) and
CD58
(combined global p = 0.008 for rs1414275-rs11588376-rs1016140). Haplotypes in
CDC42, IL19
and
IL1R1
also associated with peak anti-HBs level. We have identified strong haplotype effects on HBV vaccine-induced antibody level in five genes, three of which,
CDC42
,
IL19
and
IL1R1
, did not show evidence of association in a single SNP analyses and corroborated the majority of these effects in two datasets. The haplotype analysis identified associations with HBV vaccine-induced immunity in several new genes.
Details
- Title: Subtitle
- Host Genetic Factors and Vaccine-Induced Immunity to HBV Infection: Haplotype Analysis
- Creators
- Kelli K Ryckman - Albert Einstein Institute for Research and Education, BrazilKatherine Fielding - Albert Einstein Institute for Research and Education, BrazilAdrian V Hill - Albert Einstein Institute for Research and Education, BrazilMaimuna Mendy - Albert Einstein Institute for Research and Education, BrazilPura Rayco-Solon - Albert Einstein Institute for Research and Education, BrazilGiorgio Sirugo - Albert Einstein Institute for Research and Education, BrazilMarianne A van der Sande - Albert Einstein Institute for Research and Education, BrazilPauline Waight - Albert Einstein Institute for Research and Education, BrazilHilton C Whittle - Albert Einstein Institute for Research and Education, BrazilAndrew J Hall - Albert Einstein Institute for Research and Education, BrazilScott M Williams - Albert Einstein Institute for Research and Education, BrazilBranwen J Hennig - Albert Einstein Institute for Research and Education, Brazil
- Resource Type
- Journal article
- Publication Details
- PloS one, Vol.5(8), pp.e12273-e12273
- DOI
- 10.1371/journal.pone.0012273
- PMID
- 20806065
- PMCID
- PMC2923624
- NLM abbreviation
- PLoS One
- ISSN
- 1932-6203
- eISSN
- 1932-6203
- Publisher
- Public Library of Science
- Alternative title
- HBV Haplotype Analysis
- Language
- English
- Date published
- 2010
- Academic Unit
- Stead Family Department of Pediatrics; Epidemiology
- Record Identifier
- 9984216626802771
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