Journal article
Host-Guest Interaction Mediated Polymeric Assemblies: Multifunctional Nanoparticles for Drug and Gene Delivery
ACS nano, Vol.4(2), pp.1049-1059
02/01/2010
DOI: 10.1021/nn901213a
PMCID: PMC2835570
PMID: 20112968
Abstract
Novel core-shell structured nanoassemblies are assembled by a beta-cyclodextrin containing a positively charged host polymer and a hydrophobic guest polymer. The hydrophobic core of these types of assemblies serves as a nanocontainer to load and release the hydrophobic drugs, while the positively charged hydrophilic shell is able to condense the plasmid DNA and achieve its transfection/expression in osteoblast cells. These assemblies may be used as a new generation of multifunctional nanocarriers for simultaneous drug delivery and gene therapy.
Details
- Title: Subtitle
- Host-Guest Interaction Mediated Polymeric Assemblies: Multifunctional Nanoparticles for Drug and Gene Delivery
- Creators
- Jianxiang Zhang - University of MichiganHongli Sun - Department of Biologic and Materials SciencesPeter X. Ma - University of Michigan
- Resource Type
- Journal article
- Publication Details
- ACS nano, Vol.4(2), pp.1049-1059
- DOI
- 10.1021/nn901213a
- PMID
- 20112968
- PMCID
- PMC2835570
- NLM abbreviation
- ACS Nano
- ISSN
- 1936-0851
- eISSN
- 1936-086X
- Publisher
- Amer Chemical Soc
- Number of pages
- 11
- Grant note
- R01DE015384 / NATIONAL INSTITUTE OF DENTAL &CRANIOFACIAL RESEARCH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Dental & Craniofacial Research (NIDCR) DE015384; DE017689 / NIH (NIDCR); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Dental & Craniofacial Research (NIDCR)
- Language
- English
- Date published
- 02/01/2010
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Craniofacial Anomalies Research Center; Oral and Maxillofacial Surgery
- Record Identifier
- 9984367717902771
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