Journal article
Host Noncoding Retrotransposons Induced by DNA Viruses: a SINE of Infection?
Journal of virology, Vol.91(23), e00982-17
12/01/2017
DOI: 10.1128/JVI.00982-17
PMCID: PMC5686761
PMID: 28931686
Abstract
Our genomes are dominated by repetitive elements. The majority of these elements derive from retrotransposons, which expand throughout the genome through a process of reverse transcription and integration. Short interspersed nuclear elements, or SINEs, are an abundant class of retrotransposons that are transcribed by RNA polymerase III, thus generating exclusively noncoding RNA (ncRNA) that must hijack the machinery required for their transposition. SINE loci are generally transcriptionally repressed in somatic cells but can be robustly induced upon infection with multiple DNA viruses. Recent research has focused on the gene expression and signaling events that are modulated by SINE ncRNAs, particularly during gammaherpesvirus infection. Here, we review the biology of these SINE ncRNAs, explore how DNA virus infection may lead to their induction, and describe how novel gene regulatory and immune-related functions of these ncRNAs may impact the viral life cycle.
Details
- Title: Subtitle
- Host Noncoding Retrotransposons Induced by DNA Viruses: a SINE of Infection?
- Creators
- Jessica M Tucker - University of California, BerkeleyBritt A Glaunsinger - University of California, Berkeley
- Resource Type
- Journal article
- Publication Details
- Journal of virology, Vol.91(23), e00982-17
- DOI
- 10.1128/JVI.00982-17
- PMID
- 28931686
- PMCID
- PMC5686761
- NLM abbreviation
- J Virol
- ISSN
- 0022-538X
- eISSN
- 1098-5514
- Grant note
- R01 CA136367 / NCI NIH HHS R01 CA160556 / NCI NIH HHS
- Language
- English
- Date published
- 12/01/2017
- Academic Unit
- Microbiology and Immunology
- Record Identifier
- 9984297426102771
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