Journal article
Host defense peptides human β defensin 2 and LL-37 ameliorate murine enterocolitis
iScience, Vol.27(6), 109993
06/21/2024
DOI: 10.1016/j.isci.2024.109993
PMCID: PMC11154634
PMID: 38846005
Abstract
Necrotizing enterocolitis (NEC) is a leading cause of preterm infant morbidity and mortality. Treatment for NEC is limited and non-targeted, which makes new treatment and prevention strategies critical. Host defense peptides (HDPs) are essential components of the innate immune system and have multifactorial mechanisms in host defense. LL-37 and hBD2 are two HDPs that have been shown in prior literature to protect from neonatal sepsis-induced mortality or adult inflammatory bowel disease, respectively. Therefore, this article sought to understand if these two HDPs could influence NEC severity in murine preclinical models. NEC was induced in P14-16 C57Bl/6 mice and HDPs were provided as a pretreatment or treatment. Both LL-37 and hBD2 resulted in decreased NEC injury scores as a treatment and hBD2 as a pretreatment. Our data suggest LL-37 functions through antimicrobial properties, while hBD2 functions through decreases in inflammation and improvement of intestinal barrier integrity.
Details
- Title: Subtitle
- Host defense peptides human β defensin 2 and LL-37 ameliorate murine enterocolitis
- Creators
- Shiloh R. Lueschow-Guijosa - University of IowaAmy H. Stanford - University of IowaJennifer N. Berger - Children's MinnesotaHuiyu Gong - University of IowaTimothy J. Boly - University of IowaBenjamin A. H. Jensen - University of CopenhagenPeter Nordkild - APSAlexandra J. Leegwater - University of California, DavisJan Wehkamp - University of TübingenMark A. Underwood - University of California, DavisSteven J. McElroy - University of California, Davis
- Resource Type
- Journal article
- Publication Details
- iScience, Vol.27(6), 109993
- DOI
- 10.1016/j.isci.2024.109993
- PMID
- 38846005
- PMCID
- PMC11154634
- NLM abbreviation
- iScience
- eISSN
- 2589-0042
- Publisher
- Elsevier
- Number of pages
- 21
- Grant note
- R01DK125415 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Language
- English
- Date published
- 06/21/2024
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology; Internal Medicine
- Record Identifier
- 9984775275602771
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