Journal article
Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era
Blood, Vol.112(7), pp.2694-2702
10/01/2008
DOI: 10.1182/blood-2007-09-111658
PMCID: PMC2556607
PMID: 18633131
Abstract
To evaluate the hypothesis that host germ line variation in immune genes is associated with overall survival in diffuse large B-cell lymphoma (DLBCL), we genotyped 73 single nucleotide polymorphisms (SNPs) from 44 candidate genes in 365 DLBCL patients diagnosed from 1998 to 2000. We estimated hazard ratios (HRs) and 95% confidence intervals (CIs) for the association of SNPs with survival after adjusting for clinical factors. During follow-up, 96 (26%) patients died, and the median follow-up was 57 months for surviving patients. The observed survival of this cohort was consistent with population-based estimates conditioned on surviving 12 months. An IL10 haplotype (global P = .03) and SNPs in IL8RB (rs1126580; HR(AG/GG) = 2.11; CI, 1.28-3.50), IL1A (rs1800587; HR(CT/TT) = 1.90; CI, 1.26-2.87), TNF (rs1800629; HR(AG/GG) = 1.44; CI, 0.95-2.18), and IL4R (rs2107356; HR(CC/CT) = 1.97; CI, 1.01-3.83) were the strongest predictors of overall survival. A risk score that combined the latter 4 SNPs with clinical factors was strongly associated with survival in a Cox model (P = 6.0 x 10(-11)). Kaplan-Meier 5-year survival estimates for low, intermediate-low, intermediate-high, and high-risk patients were 94%, 79%, 60%, and 48%, respectively. These data support a role for germ line variation in immune genes, particularly genes associated with a proinflammatory state, as predictors of late survival in DLBCL.
Details
- Title: Subtitle
- Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era
- Creators
- Thomas M Habermann - Mayo Clinic College of Medicine, Rochester, MN, USASophia S WangMatthew J MaurerLindsay M MortonCharles F LynchStephen M AnsellPatricia HartgeRichard K SeversonNathaniel RothmanScott DavisSusan M GeyerWendy CozenStephen J ChanockJames R Cerhan
- Resource Type
- Journal article
- Publication Details
- Blood, Vol.112(7), pp.2694-2702
- Publisher
- United States
- DOI
- 10.1182/blood-2007-09-111658
- PMID
- 18633131
- PMCID
- PMC2556607
- ISSN
- 0006-4971
- eISSN
- 1528-0020
- Grant note
- N02-PC-71 105 / NCI NIH HHS N01-PC-67 008 / NCI NIH HHS N01-PC-65 064 / NCI NIH HHS N01-PC-67 009 / NCI NIH HHS P50 CA97274 / NCI NIH HHS R01 CA096704 / NCI NIH HHS R01 CA96704 / NCI NIH HHS N01-PC-67 010 / NCI NIH HHS P50 CA097274 / NCI NIH HHS
- Language
- English
- Date published
- 10/01/2008
- Academic Unit
- Epidemiology
- Record Identifier
- 9983995110802771
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