Journal article
Host-imposed manganese starvation of invading pathogens: two routes to the same destination
Biometals, Vol.28(3), pp.509-519
06/01/2015
DOI: 10.1007/s10534-015-9850-z
PMCID: PMC4430393
PMID: 25836716
Abstract
During infection invading pathogens must acquire all essential nutrients, including first row transition metals, from the host. To combat invaders, the host exploits this fact and restricts the availability of these nutrients using a defense mechanism known as nutritional immunity. While iron sequestration is the most well-known aspect of this defense, recent work has revealed that the host restricts the availability of other essential elements, notably manganese (Mn), during infection. Furthermore, these studies have revealed that the host utilizes multiple strategies that extend beyond metal sequestration to prevent bacteria from obtaining these metals. This review will discuss the mechanisms by which bacteria attempt to obtain the essential first row transition metal ion Mn during infection, and the approaches utilized by the host to prevent this occurrence. In addition, this review will discuss the impact of host-imposed Mn starvation on invading bacteria.
Details
- Title: Subtitle
- Host-imposed manganese starvation of invading pathogens: two routes to the same destination
- Creators
- Jacqueline R. Morey - University of AdelaideChristopher A. McDevitt - University of AdelaideThomas E. Kehl-Fie - University of Illinois Urbana-Champaign
- Resource Type
- Journal article
- Publication Details
- Biometals, Vol.28(3), pp.509-519
- Publisher
- Springer Nature
- DOI
- 10.1007/s10534-015-9850-z
- PMID
- 25836716
- PMCID
- PMC4430393
- ISSN
- 0966-0844
- eISSN
- 1572-8773
- Number of pages
- 11
- Grant note
- K22 AI104805 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA 1022240; 1080784 / National Health and Medical Research Council; National Health & Medical Research Council (NHMRC) of Australia 5-FY15-30 / March of Dimes Foundation; March of Dimes 1080784 / National Health and Medical Research Council of Australia; National Health & Medical Research Council (NHMRC) of Australia Australian Postgraduate Award; Australian Government DP120103957; DP150104515 / Australian Research Council
- Language
- English
- Date published
- 06/01/2015
- Academic Unit
- Microbiology and Immunology
- Record Identifier
- 9984618510902771
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