Journal article
Host subversion of bacterial metallophore usage drives copper intoxication
mBio, Vol.14(5), pp.e0135023-e0135023
10/31/2023
DOI: 10.1128/mbio.01350-23
PMCID: PMC10653882
PMID: 37737591
Abstract
During infection, bacteria must overcome the dual threats of metal starvation and intoxication. This work reveals that the zinc-withholding response of the host sensitizes
to copper intoxication. In response to zinc starvation,
utilizes the metallophore staphylopine. The current work revealed that the host can leverage the promiscuity of staphylopine to intoxicate
during infection. Significantly, staphylopine-like metallophores are produced by a wide range of pathogens, suggesting that this is a conserved weakness that the host can leverage to toxify invaders with copper. Moreover, it challenges the assumption that the broad-spectrum metal binding of metallophores is inherently beneficial to bacteria.
Details
- Title: Subtitle
- Host subversion of bacterial metallophore usage drives copper intoxication
- Creators
- Saika Hossain - University of Illinois Urbana-ChampaignJacqueline R Morey - University of Illinois Urbana-ChampaignStephanie L Neville - Peter Doherty InstituteKatherine Ganio - Peter Doherty InstituteJana N Radin - University of Illinois Urbana-ChampaignJaviera Norambuena - Rutgers, The State University of New JerseyJeff M Boyd - Rutgers, The State University of New JerseyChristopher A McDevitt - Peter Doherty InstituteThomas E Kehl-Fie - University of Illinois Urbana-Champaign
- Resource Type
- Journal article
- Publication Details
- mBio, Vol.14(5), pp.e0135023-e0135023
- DOI
- 10.1128/mbio.01350-23
- PMID
- 37737591
- PMCID
- PMC10653882
- NLM abbreviation
- mBio
- ISSN
- 2161-2129
- eISSN
- 2150-7511
- Grant note
- R01 AI155611 / NIAID NIH HHS R01 AI139100 / NIAID NIH HHS R01 AI118880 / NIAID NIH HHS
- Language
- English
- Date published
- 10/31/2023
- Academic Unit
- Microbiology and Immunology
- Record Identifier
- 9984618526402771
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