Journal article
House Dust Endotoxin Association with Chronic Bronchitis and Emphysema
Environmental health perspectives, Vol.126(3), pp.037007-037007
03/23/2018
DOI: 10.1289/ehp2452
PMCID: PMC6071737
PMID: 29578323
Abstract
Endotoxin has been reported to be associated with chronic bronchitis or emphysema (CBE) at high occupational exposures. However, whether levels found in domestic environments have similar effects is unknown.
We aimed to study the association between house dust endotoxin and CBE in a sample representative of the U.S. population.
We analyzed data from 3,393 participants ≥20 y old from the National Health and Nutrition Examination Survey (NHANES) 2005-2006. House dust from bedding and from bedroom floors was analyzed for endotoxin content. NHANES participants received questionnaires and underwent examination as well as extensive laboratory testing. Logistic regression was used to examine the association of endotoxin levels with CBE diagnosis and symptoms, adjusting for covariates. The survey design and weights were applied so that estimates were nationally representative and so that statistical inferences were made appropriately.
The median endotoxin concentration in house dust was 14.61 EU/mg dust, and CBE was reported by 8.2% of participants. In the adjusted analysis, one unit (EU/mg) increase in log
-transformed endotoxin concentrations was associated with a 27% increase in the odds of CBE diagnosis [OR=1.27 (95% CI: 1.00, 1.61)] and a 78% increase in the odds of chronic bronchitis symptoms (defined as cough and phlegm for ≥3 mo in a year for ≥2 y) [OR=1.78 (95% CI: 1.01, 3.12)]. Sensitization to inhalant allergens (
=0.001) modified the relationship between endotoxin and CBE diagnosis, with stronger associations observed in sensitized participants [OR=2.46 (95% CI: 1.72, 3.50) for a unit increase in log
-endotoxin].
In a population-based sample of U.S. adults, endotoxin levels in homes were associated with a self-reported history of CBE diagnosis and chronic bronchitis symptoms, with stronger associations among people sensitized to inhalant allergens. https://doi.org/10.1289/EHP2452.
Details
- Title: Subtitle
- House Dust Endotoxin Association with Chronic Bronchitis and Emphysema
- Creators
- Angelico Mendy - Department of Occupational and Environmental Health, University of Iowa, Iowa City, Iowa, USAPäivi M Salo - Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USARichard D Cohn - Social & Scientific Systems, Inc., Durham, North Carolina, USAJesse Wilkerson - Social & Scientific Systems, Inc., Durham, North Carolina, USADarryl C Zeldin - Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USAPeter S Thorne - Department of Occupational and Environmental Health, University of Iowa, Iowa City, Iowa, USA
- Resource Type
- Journal article
- Publication Details
- Environmental health perspectives, Vol.126(3), pp.037007-037007
- Publisher
- United States
- DOI
- 10.1289/ehp2452
- PMID
- 29578323
- PMCID
- PMC6071737
- ISSN
- 1552-9924
- eISSN
- 1552-9924
- Grant note
- P30 ES005605 / NIEHS NIH HHS Z01 ES025041 / Intramural NIH HHS
- Language
- English
- Date published
- 03/23/2018
- Academic Unit
- Civil and Environmental Engineering; Occupational and Environmental Health
- Record Identifier
- 9983997453602771
Metrics
17 Record Views