Journal article
House Dust Endotoxin and Peripheral Leukocyte Counts: Results from Two Large Epidemiologic Studies
Environmental health perspectives, Vol.125(5), pp.057010-057010
05/31/2017
DOI: 10.1289/ehp661
PMCID: PMC5730525
PMID: 28599265
Abstract
The peripheral leukocyte count is a biomarker of inflammation and is associated with human all-cause mortality. Although causes of acute leukocytosis are well-described, chronic environmental determinants of leukocyte number are less well understood.
We investigated the relationship between house dust endotoxin concentration and peripheral leukocyte counts in human subjects.
The endotoxin–leukocyte relationship was evaluated by linear regression in the National Health and Nutrition Examination Survey (NHANES) 2005–2006 (n=6,254) and the Agricultural Lung Health Study (ALHS; n=1,708). In the ALHS, we tested for a gene [Toll-like Receptor 4 (
), encoding the endotoxin receptor]-by-environment interaction in the endotoxin–leukocyte relationship using regression models with an interaction term.
There is a statistically significant, positive association between endotoxin concentration and total leukocyte number [estimated change, 0.186×10
/μL (95% CI: 0.070, 0.301×10
/μL) per 10-fold change in endotoxin; p=0.004) in the NHANES. Similar positive associations were found for monocytes, lymphocytes, and neutrophils. Stratified analyses revealed possible effect modification by asthma and chronic obstructive pulmonary disease. We observed similar associations in the ALHS. For total leukocytes, there was suggestive evidence in the ALHS of a gene-by-environment interaction for minor allele carrier status at the
haplotype defined by rs4986790 and rs4986791 (interaction p=0.15).
This is, to our knowledge, the first report of an association between house dust endotoxin and leukocyte count in a national survey. The finding was replicated in a farming population. Peripheral leukocyte count may be influenced by residential endotoxin exposure in diverse settings. https://doi.org/10.1289/EHP661.
Details
- Title: Subtitle
- House Dust Endotoxin and Peripheral Leukocyte Counts: Results from Two Large Epidemiologic Studies
- Creators
- Michael B Fessler - Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina, USAMegan U Carnes - Epidemiology Branch, NIEHS, NIH, DHHS, Research Triangle Park, North Carolina, USAPäivi M Salo - Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina, USAJesse Wilkerson - Social & Scientific Systems, Inc., Durham, North Carolina, USARichard D Cohn - Social & Scientific Systems, Inc., Durham, North Carolina, USADebra King - Clinical Pathology Group, NIEHS, NIH, DHHS, Research Triangle Park, North Carolina, USAJane A Hoppin - Department of Biological Sciences and Center for Human Health and the Environment, North Carolina State University, Raleigh, North Carolina, USADale P Sandler - Epidemiology Branch, NIEHS, NIH, DHHS, Research Triangle Park, North Carolina, USAGreg Travlos - Clinical Pathology Group, NIEHS, NIH, DHHS, Research Triangle Park, North Carolina, USAStephanie London - Epidemiology Branch, NIEHS, NIH, DHHS, Research Triangle Park, North Carolina, USAPeter Thorne - Department of Occupational and Environmental Health, College of Public Health, University of Iowa, Iowa City, Iowa 52242, USADarryl Zeldin - Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina, USA
- Resource Type
- Journal article
- Publication Details
- Environmental health perspectives, Vol.125(5), pp.057010-057010
- Publisher
- United States
- DOI
- 10.1289/ehp661
- PMID
- 28599265
- PMCID
- PMC5730525
- ISSN
- 1552-9924
- eISSN
- 1552-9924
- Grant note
- Z01 ES102005 / Intramural NIH HHS P30 ES005605 / NIEHS NIH HHS Z01 CP010119 / Intramural NIH HHS Z01 ES025041 / Intramural NIH HHS Z01 ES049030 / Intramural NIH HHS
- Language
- English
- Date published
- 05/31/2017
- Academic Unit
- Civil and Environmental Engineering; Occupational and Environmental Health
- Record Identifier
- 9983997456002771
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