Household endotoxin levels and the risk of non-Hodgkin lymphoma

Jun Wang; Wendy Cozen; Peter S Thorne; Kiros Berhane; James R Cerhan; Patricia Hartge; Mary H Ward; Anneclaire J De Roos; Richard K Severson; Lindsay M Morton; Leslie Bernstein; Martha S Linet; Joanne S Colt

doi:10.1007/s10552-012-0121-9

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Household endotoxin levels and the risk of non-Hodgkin lymphoma

Journal article

Open access

Peer reviewed

Household endotoxin levels and the risk of non-Hodgkin lymphoma

Jun Wang, Wendy Cozen, Peter S Thorne, Kiros Berhane, James R Cerhan, Patricia Hartge, Mary H Ward, Anneclaire J De Roos, Richard K Severson, Lindsay M Morton, …

Cancer causes & control, Vol.24(2), pp.357-364

02/2013

DOI: 10.1007/s10552-012-0121-9

PMCID: PMC3800025

PMID: 23277417

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https://www.ncbi.nlm.nih.gov/pmc/articles/3800025View

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Abstract

Endotoxin, a component of the outer membrane of gram-negative bacteria, elicits a strong innate and inflammatory immune response associated with the secretion of proinflammatory cytokines, including tumor necrosis factor-alpha (TNF-α). Because TNF-α polymorphisms that increase TNF-α production are associated with an increased risk of non-Hodgkin lymphoma (NHL), we hypothesized that increased levels of household endotoxin would be associated with an increased NHL risk. We evaluated this association in the National Cancer Institute/Surveillance, Epidemiology and End Results (NCI/SEER) NHL multicenter population-based case-control study. Used vacuum cleaner bags were collected from participants during a home interview. Dust samples from the bags of 594 cases and 442 controls were analyzed for endotoxin [endotoxin unit (EU)/mg of dust] using the kinetic chromogenic Limulus amebocyte lysate assay. Multivariable logistic regression was used to estimate the effect of endotoxin on NHL risk adjusted for age, sex, race, education, study center, and farm exposure. Endotoxin was not associated with NHL overall [odds ratio (OR) for highest quartile of endotoxin levels = 0.81, 95 % confidence interval (CI) = 0.55, 1.20; p for trend = 0.35] or with diffuse large B-cell lymphoma (OR = 0.63, 95 % CI = 0.34, 1.16; p = 0.31) or follicular lymphoma (OR = 1.07, 95 % CI = 0.61, 1.89; p = 0.73) subtypes. Both working and living on a farm were associated with higher household endotoxin levels compared to never working (p = 0.009) or living (p = 0.01) on a farm. Excluding farmers from the analysis did not change the results. We found no evidence of a role for household endotoxin in NHL etiology.

Lymphoma, Non-Hodgkin - chemically induced

United States - epidemiology

Genetic Predisposition to Disease

SEER Program

Endotoxins - poisoning

Humans

Middle Aged

Risk Factors

Male

Lymphoma, Non-Hodgkin - genetics

Lymphoma, Non-Hodgkin - epidemiology

Case-Control Studies

Environmental Exposure - adverse effects

Family Characteristics

Female

Aged

Details

Title: Subtitle: Household endotoxin levels and the risk of non-Hodgkin lymphoma
Creators: Jun Wang - Department of Preventive Medicine, USC Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Wendy Cozen
Peter S Thorne
Kiros Berhane
James R Cerhan
Patricia Hartge
Mary H Ward
Anneclaire J De Roos
Richard K Severson
Lindsay M Morton
Leslie Bernstein
Martha S Linet
Joanne S Colt
Resource Type: Journal article
Publication Details: Cancer causes & control, Vol.24(2), pp.357-364
DOI: 10.1007/s10552-012-0121-9
PMID: 23277417
PMCID: PMC3800025
NLM abbreviation: Cancer Causes Control
ISSN: 0957-5243
eISSN: 1573-7225
Publisher: Netherlands
Grant note: P01 CA17054 / NCI NIH HHS P30 ES005605 / NIEHS NIH HHS P30 ES07048 / NIEHS NIH HHS U55/CCR921930-02 / PHS HHS N01 PC067008 / NCI NIH HHS N01 PC065064 / NCI NIH HHS N01PC35139 / NCI NIH HHS N01-PC67009 / NCI NIH HHS ZIA CP010125-15 / Intramural NIH HHS P01 CA017054 / NCI NIH HHS N01-PC-71105 / NCI NIH HHS N01-PC-35139 / NCI NIH HHS P30 CA014089 / NCI NIH HHS N01 PC067009 / NCI NIH HHS P30 ES007048 / NIEHS NIH HHS
Language: English
Date published: 02/2013
Academic Unit: Civil and Environmental Engineering; Occupational and Environmental Health; Epidemiology
Record Identifier: 9983997301402771

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