Journal article
Household endotoxin reduction in the Louisa Environmental Intervention Project for rural childhood asthma
Indoor air, Vol.30(1), pp.88-97
01/2020
DOI: 10.1111/ina.12610
PMCID: PMC7889405
PMID: 31605641
Abstract
Endotoxin exacerbates asthma. We designed the Louisa Environmental Intervention Project (LEIP) and assessed its effectiveness in reducing household endotoxin and improving asthma symptoms in rural Iowa children. Asthmatic school children (N = 104 from 89 homes) of Louisa and Keokuk counties in Iowa (aged 5-14 years) were recruited and block-randomized to receive extensive (education + professional cleaning) or educational interventions. Environmental sampling collection and respiratory survey administration were done at baseline and during three follow-up visits. Mixed-model analyses were used to assess the effect of the intervention on endotoxin levels and asthma symptoms in the main analysis and of endotoxin reduction on asthma symptoms in exploratory analysis. In the extensive intervention group, dust endotoxin load was significantly reduced in post-intervention visits. The extensive compared with the educational intervention was associated with significantly decreased dust endotoxin load in farm homes and less frequent nighttime asthma symptoms. In exploratory analysis, dust endotoxin load reduction from baseline was associated with lower total asthma symptoms score (Odds ratio: 0.52, 95% confidence interval: 0.29-0.92). In conclusion, the LEIP intervention reduced household dust endotoxin and improved asthma symptoms. However, endotoxin reductions were not sustained post-intervention by residents.
Details
- Title: Subtitle
- Household endotoxin reduction in the Louisa Environmental Intervention Project for rural childhood asthma
- Creators
- Angelico Mendy - Departments of Occupational and Environmental Health, College of Public Health, University of Iowa, Iowa City, IowaNervana Metwali - Departments of Occupational and Environmental Health, College of Public Health, University of Iowa, Iowa City, IowaSarah S Perry - Departments of Occupational and Environmental Health, College of Public Health, University of Iowa, Iowa City, IowaElizabeth A Chrischilles - Departments of Epidemiology, College of Public Health, University of Iowa, Iowa City, IowaKai Wang - Departments of Biostatistics, College of Public Health, University of Iowa, Iowa City, IowaPeter S Thorne - Departments of Occupational and Environmental Health, College of Public Health, University of Iowa, Iowa City, Iowa
- Resource Type
- Journal article
- Publication Details
- Indoor air, Vol.30(1), pp.88-97
- DOI
- 10.1111/ina.12610
- PMID
- 31605641
- PMCID
- PMC7889405
- NLM abbreviation
- Indoor Air
- ISSN
- 1600-0668
- eISSN
- 1600-0668
- Publisher
- England
- Grant note
- NIH P30 ES005605 / NIEHS NIH HHS NIH R01 ES11392 / NIEHS NIH HHS
- Language
- English
- Date published
- 01/2020
- Academic Unit
- Pharmacy; Civil and Environmental Engineering; Occupational and Environmental Health; Epidemiology; Biostatistics
- Record Identifier
- 9984001088402771
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