Journal article
Household transmission of carbapenemase-producing Enterobacteriaceae: a prospective cohort study
Journal of antimicrobial chemotherapy, Vol.76(5), pp.1299-1302
04/13/2021
DOI: 10.1093/jac/dkaa561
PMID: 33417711
Abstract
To estimate the transmission rate of carbapenemase-producing Enterobacteriaceae (CPE) in households with recently hospitalized CPE carriers.
We conducted a prospective case-ascertained cohort study. We identified the presence of CPE in stool samples from index subjects, household contacts and companion animals and environmental samples at regular intervals. Linked transmissions were identified by WGS. A Markov model was constructed to estimate the household transmission potential of CPE.
Ten recently hospitalized index patients and 14 household contacts were included. There were seven households with one contact, two households with two contacts, and one household with three contacts. Index patients were colonized with blaOXA-48-like (n = 4), blaKPC-2 (n = 3), blaIMP (n = 2), and blaNDM-1 (n = 1), distributed among divergent species of Enterobacteriaceae. After a cumulative follow-up time of 9.0 years, three family members (21.4%, 3/14) acquired four different types of CPE in the community (hazard rate of 0.22/year). The probability of CPE transmission from an index patient to a household contact was 10% (95% CI 4%-26%).
We observed limited transmission of CPE from an index patient to household contacts. Larger studies are needed to understand the factors associated with household transmission of CPE and identify preventive strategies.
Details
- Title: Subtitle
- Household transmission of carbapenemase-producing Enterobacteriaceae: a prospective cohort study
- Creators
- Kalisvar Marimuthu - Yong Loo Lin School of Medicine, National University of Singapore, SingaporeYin Mo - Division of Infectious Diseases, National University Hospital, SingaporeMoi Lin Ling - Department of Infection Prevention and Epidemiology, Singapore General Hospital, SingaporeAnastasia Hernandez-Koutoucheva - Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Salaya, ThailandShannon N Fenlon - Laboratory of Bacterial Genomics, Genome Institute of Singapore, SingaporeDenis Bertrand - Computational and Systems Biology, Genome Institute of Singapore, SingaporeDavid Chien Lye - Lee Kong Chian School of Medicine, Nanyang Technological University, SingaporeBrenda Sze Peng Ang - Department of Infection Prevention and Control, Tan Tock Seng Hospital, SingaporeEli Perencevich - Carver College of Medicine, University of Iowa, Iowa City, IA, USAOon Tek Ng - Lee Kong Chian School of Medicine, Nanyang Technological University, SingaporeBen S Cooper - Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, UKNiranjan Nagarajan - Computational and Systems Biology, Genome Institute of Singapore, SingaporeSwaine L Chen - Laboratory of Bacterial Genomics, Genome Institute of Singapore, SingaporeTimothy Barkham - Department of Laboratory Medicine, Tan Tock Seng Hospital, Singapore
- Resource Type
- Journal article
- Publication Details
- Journal of antimicrobial chemotherapy, Vol.76(5), pp.1299-1302
- DOI
- 10.1093/jac/dkaa561
- PMID
- 33417711
- NLM abbreviation
- J Antimicrob Chemother
- eISSN
- 1460-2091
- Publisher
- England
- Grant note
- MR/R004536/1 / Medical Research Council MR/K006924/1 / Medical Research Council
- Language
- English
- Date published
- 04/13/2021
- Academic Unit
- Epidemiology; Internal Medicine
- Record Identifier
- 9984077777002771
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