Journal article
How Can Hearing Loss Cause Dementia?
Neuron (Cambridge, Mass.), Vol.108(3), pp.401-412
11/11/2020
DOI: 10.1016/j.neuron.2020.08.003
PMID: 32871106
Abstract
Epidemiological studies identify midlife hearing loss as an independent risk factor for dementia, estimated to account for 9% of cases. We evaluate candidate brain bases for this relationship. These bases include a common pathology affecting the ascending auditory pathway and multimodal cortex, depletion of cognitive reserve due to an impoverished listening environment, and the occupation of cognitive resources when listening in difficult conditions. We also put forward an alternate mechanism, drawing on new insights into the role of the medial temporal lobe in auditory cognition. In particular, we consider how aberrant activity in the service of auditory pattern analysis, working memory, and object processing may interact with dementia pathology in people with hearing loss. We highlight how the effect of hearing interventions on dementia depends on the specific mechanism and suggest avenues for work at the molecular, neuronal, and systems levels to pin this down.
Griffiths et al. evaluate candidate explanations for the relationship between hearing loss and dementia. As well as considering common pathology, impoverished input, and resource competition, they develop a novel account based on specific interactions between auditory cognition and dementia pathology in the medial temporal lobe.
Details
- Title: Subtitle
- How Can Hearing Loss Cause Dementia?
- Creators
- Timothy D Griffiths - Biosciences Institute, Newcastle University Medical School, Newcastle upon Tyne NE2 4HH, UKMeher Lad - Biosciences Institute, Newcastle University Medical School, Newcastle upon Tyne NE2 4HH, UKSukhbinder Kumar - Biosciences Institute, Newcastle University Medical School, Newcastle upon Tyne NE2 4HH, UKEmma Holmes - Wellcome Centre for Human Neuroimaging, UCL Queen Square Institute of Neurology, University College London, London WC1N 3AR, UKBob McMurray - Departments of Psychological and Brain Sciences, Communication Sciences and Disorders, Otolaryngology, University of Iowa, Iowa City, IA 52242, USAEleanor A Maguire - Wellcome Centre for Human Neuroimaging, UCL Queen Square Institute of Neurology, University College London, London WC1N 3AR, UKAlexander J Billig - UCL Ear Institute, University College London, London WC1X 8EE, UKWilliam Sedley - Biosciences Institute, Newcastle University Medical School, Newcastle upon Tyne NE2 4HH, UK
- Resource Type
- Journal article
- Publication Details
- Neuron (Cambridge, Mass.), Vol.108(3), pp.401-412
- DOI
- 10.1016/j.neuron.2020.08.003
- PMID
- 32871106
- NLM abbreviation
- Neuron
- ISSN
- 0896-6273
- eISSN
- 1097-4199
- Publisher
- Elsevier Inc
- Grant note
- DOI: 10.13039/100000002, name: National Institutes of Health, award: 2R01DC004290, 5P50DC000242-33, 210567/Z/18/Z, WT106964MA, MR/T032553/1; DOI: 10.13039/100010269, name: Wellcome Trust, award: 2R01DC004290, 5P50DC000242-33, 210567/Z/18/Z, WT106964MA, MR/T032553/1; DOI: 10.13039/501100000703, name: Action on Hearing Loss, award: 2R01DC004290, 5P50DC000242-33, 210567/Z/18/Z, WT106964MA, MR/T032553/1; DOI: 10.13039/501100000265, name: Medical Research Council, award: 2R01DC004290, 5P50DC000242-33, 210567/Z/18/Z, WT106964MA, MR/T032553/1
- Language
- English
- Date published
- 11/11/2020
- Academic Unit
- Communication Sciences and Disorders; Linguistics; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neurosurgery; Otolaryngology
- Record Identifier
- 9984070374402771
Metrics
27 Record Views