Journal article
How Different Aspects of Motor Dysfunction Influence Day-to-Day Function in Huntington’s Disease
Movement disorders, Vol.34(12), pp.1910-1914
12/2019
DOI: 10.1002/mds.27866
PMCID: PMC7025393
PMID: 31609508
Abstract
Purpose: This study examined the relationships between different aspects of motor dysfunction (chorea, dystonia, rigidity, incoordination, oculomotor dysfunction, dysarthria, and gait difficulties) and functional status in persons with Huntington's disease. Methods: A total of 527 persons with Huntington's disease completed the Unified Huntington's Disease Rating Scale motor, total functional capacity, and functional assessments. Results: Confirmatory factor analysis indicated that a 4-factor model provided a better model fit than the existing 5-factor model. Exploratory factor analysis identified the following 4 factors from the motor scale: dystonia, chorea, rigidity, and a general motor factor. Regression indicated that dystonia (β = −0.47 and −0.79) and rigidity (β = −0.28 and −0.59) had strong associations with function, whereas chorea had modest correlations (β = −0.16 and −0.15). Conclusions: Dystonia and rigidity have stronger relationships with functional status than chorea in persons with Huntington's disease. The findings underscore the need for further research regarding the effects of dystonia and rigidity on functioning. © 2019 International Parkinson and Movement Disorder Society.
Details
- Title: Subtitle
- How Different Aspects of Motor Dysfunction Influence Day-to-Day Function in Huntington’s Disease
- Creators
- Noelle E. Carlozzi - University of MichiganStephen G. Schilling - University of MichiganNicholas R. Boileau - University of MichiganKelvin L. Chou - University of IowaJoel S. Perlmutter - Washington University in St. LouisSamuel Frank - Beth Israel Deaconess Medical CenterMichael K. McCormack - Rutgers, The State University of New JerseyJulie C. Stout - Monash UniversityJane S. Paulsen - University of IowaJin-Shei Lai - Northwestern UniversityPraveen Dayalu - University of Michigan
- Resource Type
- Journal article
- Publication Details
- Movement disorders, Vol.34(12), pp.1910-1914
- DOI
- 10.1002/mds.27866
- PMID
- 31609508
- PMCID
- PMC7025393
- NLM abbreviation
- Mov Disord
- ISSN
- 0885-3185
- eISSN
- 1531-8257
- Grant note
- DOI: 10.13039/100005725, name: CHDI Foundation; DOI: 10.13039/100006108, name: National Center for Advancing Translational Sciences, award: UL1TR000433; DOI: 10.13039/100000065, name: National Institute of Neurological Disorders and Stroke, award: R01NS040068, R01NS077946
- Language
- English
- Date published
- 12/2019
- Academic Unit
- Psychiatry; Psychological and Brain Sciences
- Record Identifier
- 9984383291702771
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