How Many Cores Should Be Collected per Region of Interest in Fusion Targeted Prostate Biopsy? A Retrospective Single Institution Statistical Simulation

Casey N Brodsky; Stephanie Daignault-Newton; Matthew S Davenport; Kathryn A Marchetti; Meidee Goh; John T Wei

doi:10.1016/j.urology.2024.12.033

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How Many Cores Should Be Collected per Region of Interest in Fusion Targeted Prostate Biopsy? A Retrospective Single Institution Statistical Simulation

Journal article

Peer reviewed

How Many Cores Should Be Collected per Region of Interest in Fusion Targeted Prostate Biopsy? A Retrospective Single Institution Statistical Simulation

Casey N Brodsky, Stephanie Daignault-Newton, Matthew S Davenport, Kathryn A Marchetti, Meidee Goh and John T Wei

Urology (Ridgewood, N.J.), Vol.197, pp.133-140

03/2025

DOI: 10.1016/j.urology.2024.12.033

PMID: 39730113

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Abstract

To determine how many cores should be collected per region of interest (ROI) in magnetic resonance imaging-guided fusion prostate biopsy. Magnetic resonance imaging-guided targeted prostate biopsy has led to improved detection of clinically significant prostate cancer (csPC); however, data is limited regarding the optimal number of biopsy cores that should be taken. An ideal number of cores maximizes clinically significant cancer detection while minimizing cost, discomfort, and procedure time. Patients receiving targeted prostate biopsy (4 cores per ROI) combined with systematic 12-core prostate at our institution between January 2017 and June 2022 were retrospectively identified. Statistical simulation was used to model scenarios in which 1, 2, 3, or 4 cores were taken from the ROI, and the rate of grade group ≥2 prostate cancer (csPC) detection was determined for targeted and combined targeted plus systematic biopsy. 483 patients were identified. Transrectal (96%) and transperineal (4%) biopsies were included. For targeted biopsy, csPC was present in 21% (1 core), 26% (2 cores; P = .048), 29% (3 cores; P = .002), and 31% (4 cores; P < .001) of cases. For combined biopsy, csPC was present in 33% (1 core), 35% (2 cores; P = .4), 37% (3 cores; P = .2), and 38% (4 cores; P = .12) of cases. If targeted biopsy is performed without systematic biopsy, 2 or more cores is superior to 1 core for detecting csPC. This effect is mitigated when targeted and systematic biopsy are combined.

Aged

Biopsy, Large-Core Needle - methods

Biopsy, Large-Core Needle - statistics & numerical data

Humans

Image-Guided Biopsy - methods

Image-Guided Biopsy - statistics & numerical data

Magnetic Resonance Imaging, Interventional

Male

Middle Aged

Prostate - diagnostic imaging

Prostate - pathology

Prostatic Neoplasms - diagnosis

Prostatic Neoplasms - pathology

Retrospective Studies

Details

Title: Subtitle: How Many Cores Should Be Collected per Region of Interest in Fusion Targeted Prostate Biopsy? A Retrospective Single Institution Statistical Simulation
Creators: Casey N Brodsky - University of Michigan
Stephanie Daignault-Newton - University of Michigan
Matthew S Davenport - University of Michigan
Kathryn A Marchetti - University of Pittsburgh Medical Center
Meidee Goh - University of Michigan
John T Wei - University of Michigan
Resource Type: Journal article
Publication Details: Urology (Ridgewood, N.J.), Vol.197, pp.133-140
DOI: 10.1016/j.urology.2024.12.033
PMID: 39730113
NLM abbreviation: Urology
ISSN: 0090-4295
eISSN: 1527-9995
Language: English
Date published: 03/2025
Academic Unit: Urology
Record Identifier: 9984848506502771

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