How Ubiquitin Functions with ESCRTs

S. Brookhart Shields; Robert C. Piper

doi:10.1111/j.1600-0854.2011.01242.x

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Journal article

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How Ubiquitin Functions with ESCRTs

S. Brookhart Shields and Robert C. Piper

Traffic (Copenhagen, Denmark), Vol.12(10), pp.1306-1317

10/01/2011

DOI: 10.1111/j.1600-0854.2011.01242.x

PMCID: PMC3171646

PMID: 21722280

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Abstract

The endosomal-sorting complex required for transport (ESCRT) apparatus has multiple ubiquitin (Ub)-binding domains and participates in a wide variety of cellular processes. Many of these ESCRT-dependent processes are keenly regulated by Ub, which serves as a lysosomal-sorting signal for membrane proteins targeted into multivesicular bodies (MVBs) and which may serve as a mediator of viral budding from the cell surface. Hints that both ESCRTs and Ub work together in the processes such as cytokinesis, transcription and autophagy are beginning to emerge. Here, we explore the relationship between ESCRTs and Ub in MVB sorting and viral budding.

Cell Biology

Life Sciences & Biomedicine

Science & Technology

Details

Title: Subtitle: How Ubiquitin Functions with ESCRTs
Creators: S. Brookhart Shields - Roy J. and Lucille A. Carver College of Medicine
Robert C. Piper - Roy J. and Lucille A. Carver College of Medicine
Resource Type: Journal article
Publication Details: Traffic (Copenhagen, Denmark), Vol.12(10), pp.1306-1317
DOI: 10.1111/j.1600-0854.2011.01242.x
PMID: 21722280
PMCID: PMC3171646
NLM abbreviation: Traffic
ISSN: 1398-9219
eISSN: 1600-0854
Publisher: Wiley
Number of pages: 12
Grant note: T32DK007690 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) R01GM058202 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS) 2R01GM058202-13; 5T32DK007690-19 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
Language: English
Date published: 10/01/2011
Academic Unit: Molecular Physiology and Biophysics; Medicine Administration; Internal Medicine
Record Identifier: 9984297602902771

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