Journal article
How autologous platelet-rich plasma affects pregnancy and birth outcomes in women with repeated embryo implantation failure: A prisma-compliant meta-analysis
Turkish journal of obstetrics and gynecology, Vol.20(2), pp.154-163
06/01/2023
DOI: 10.4274/tjod.galenos.2023.46588
PMCID: PMC10236229
PMID: 37260250
Abstract
Repeated implantation failure refer to failure to conceive after three or more embryo transfer attempts. Several interventions were offered to improve maternal and fetal outcomes. Our objective was to investigate the impact of platelet-rich plasma (PRP) as a promising intervention to improve both pregnancy and birth outcomes. We searched PubMed, Scopus, Web of Science, and Cochrane Central, in addition to other relevant resources of grey literature. Only clinical trials were eligible to be included. We performed the meta-analysis using a random effects model. Eight randomized clinical trials, enrolling 1038 women with more than 3 implantation failure attempts, were included. We found a significant increase regarding all our prespecified primary outcomes. Chemical pregnancy rate [relative ratio (RR): 1.96, 95% confidence interval (CI): 1.61, 2.39; p<0.001], clinical pregnancy rate (RR: 4.35, 95% CI: 1.92, 2.88; p<0.001), and live birth rate (RR: 4.03, 95% CI: 1.29, 12.63; p=0.02) were found to be statistically significant and increased in patients who received PRP compared with the control group. Implantation rate (RR: 1.98, 95% CI: 1.34, 2.75; p<0.001), miscarriage rate (RR: 0.44, 95% CI: 0.23, 0.83, p=0.01), and multiple pregnancy rate (RR: 2.56, 95% CI: 1.02, 6.42, p=0.04) were also found to be significantly increased in the PRP group. We provide strong evidence on how intrauterine PRP can improve implantation, pregnancy, and birth outcomes in RIF women, which should direct clinicians to consider this intervention as a very effective tool in assisted reproductive techniques.
Details
- Title: Subtitle
- How autologous platelet-rich plasma affects pregnancy and birth outcomes in women with repeated embryo implantation failure: A prisma-compliant meta-analysis
- Creators
- Ahmed Soliman - Scientific Research Group in EgyptSaif Elsonbaty - Mansoura UniversityYehia Saleh - Mansoura UniversityDana Hegazy - Mansoura UniversityHazem Metwally Faragallah - Ain Shams University
- Resource Type
- Journal article
- Publication Details
- Turkish journal of obstetrics and gynecology, Vol.20(2), pp.154-163
- DOI
- 10.4274/tjod.galenos.2023.46588
- PMID
- 37260250
- PMCID
- PMC10236229
- NLM abbreviation
- Turk J Obstet Gynecol
- ISSN
- 2149-9322
- eISSN
- 2149-9330
- Language
- English
- Date published
- 06/01/2023
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984755388102771
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