Journal article
How stable are Parkinson's disease subtypes in de novo patients: Analysis of the PPMI cohort?
Parkinsonism & related disorders, Vol.28, pp.62-67
07/2016
DOI: 10.1016/j.parkreldis.2016.04.027
PMID: 27132498
Abstract
To determine the frequency and stability over time of the subgroup characterization of the tremor dominant (TD) versus postural instability gait disorder dominant (PIGD) Parkinson's disease (PD) in de novo patients.
There is a substantial body of literature on the clinical sub classification of PD into TD versus PIGD subtype. However, there are limited data on the stability of this classification especially in early disease.
Parkinson's Progression Markers Initiative (PPMI) is a longitudinal case control study of de novo, untreated PD participants at enrollment. Participants undergo a number of assessments including the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS). TD versus PIGD subtype was defined based on the previously published formula. We report one-year analysis data.
320 of 423 PD recruited subjects had data on subtype classification at year 1 and were included in the analysis. 228 (71%) were classified as TD, 56 (18%) as PIGD and 36 (11%) as indeterminate at baseline. At 12 months, 39% PIGD and 18% TD shifted subtypes: 29% PIGD shifted to TD and 11% to Indeterminate; 10% TD shifted to PIGD and 8% to Indeterminate. The classification was not affected by the dopaminergic treatment (p = 0.59).
TD versus PIGD subtype classification has substantial variability over first year in PD de novo cohort specifically for PIGD subtype. Dopaminergic therapy does not impact the change of the PD subtype. This instability has to be taken into consideration specifically when establishing correlations with the biomarkers and for long term prognostication.
•The TD/PIGD subtype classification in early Parkinson's disease (PD) has significant variability.•The change in classification is highest in the PIGD subset.•Dopaminergic therapy does not impact the change of the PD subtype.
Details
- Title: Subtitle
- How stable are Parkinson's disease subtypes in de novo patients: Analysis of the PPMI cohort?
- Creators
- Tanya Simuni - Northwestern University Feinberg School of Medicine, United StatesChelsea Caspell-Garcia - The University of Iowa, United StatesChristopher Coffey - The University of Iowa, United StatesShirley Lasch - Institute for Neurodegenerative Disorders, United StatesCaroline Tanner - University of California San Francisco, United StatesKen Marek - Institute for Neurodegenerative Disorders, United StatesPPMI Investigators
- Resource Type
- Journal article
- Publication Details
- Parkinsonism & related disorders, Vol.28, pp.62-67
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/j.parkreldis.2016.04.027
- PMID
- 27132498
- ISSN
- 1353-8020
- eISSN
- 1873-5126
- Grant note
- DOI: 10.13039/100000049, name: National Institute on Aging; DOI: 10.13039/100004319, name: Pfizer; DOI: 10.13039/100000050, name: National Heart, Lung, and Blood Institute, award: 07/15/2013-06/30/2018, 08/01/09-02/28/15, 08/05/2012-07/31/2015, 09/15/2013-07/31/2018, 12/01/09-12/31/13, U01 HL091843, U01 NS038529, U01 NS079163, U01 NS082329, U01 NS084495; DOI: 10.13039/100006259, name: Teva Pharmaceutical Industries; DOI: 10.13039/100000065, name: National Institute of Neurological Disorders and Stroke; DOI: 10.13039/100000864, name: Michael J. Fox Foundation for Parkinson's Research; DOI: 10.13039/100000002, name: National Institutes of Health, award: 10/01/11-09/30/16, 10/01/11-09/30/18, U01 NS077108, U01 NS077352; DOI: 10.13039/100001262, name: National Parkinson Foundation; DOI: 10.13039/100000005, name: U.S. Department of Defense; DOI: 10.13039/100001288, name: Parkinson's Disease Foundation
- Language
- English
- Date published
- 07/2016
- Academic Unit
- Biostatistics
- Record Identifier
- 9983997313702771
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