Journal article
Human Auditory Cortex Neurochemistry Reflects the Presence and Severity of Tinnitus
The Journal of neuroscience, Vol.35(44), pp.14822-14828
11/04/2015
DOI: 10.1523/JNEUROSCI.2695-15.2015
PMCID: PMC4635131
PMID: 26538652
Abstract
It is not known why tinnitus occurs in some cases of hearing damage but not others. Abnormalities of excitation-inhibition balance could influence whether tinnitus develops and its severity if it does. Animal models of hearing damage, which also produce tinnitus based on behavioral evidence, have identified abnormalities of GABAergic inhibition, both cortically and subcortically. However, the precise relationships of GABA inhibitory changes to tinnitus itself, as opposed to other consequences of hearing damage, remain uncertain. Here, we used magnetic resonance spectroscopy to non-invasively quantify GABA in the left (LAC) and right (RAC) auditory cortices of a group of 14 patients with lateralized tinnitus (eight left ear) and 14 controls matched for age, sex, and hearing. We also explored the potential relationships with other brain metabolites (i.e., choline, N-acetylaspartate, and creatine). The presence of tinnitus was associated with a reduction in auditory cortex GABA concentration. Regardless of tinnitus laterality, post hoc testing indicated reductions that were significant in RAC and nonsignificant in LAC. Tinnitus severity and hearing loss were correlated positively with RAC choline but not GABA. We discuss the results in the context of current models of tinnitus and methodological constraints.
Details
- Title: Subtitle
- Human Auditory Cortex Neurochemistry Reflects the Presence and Severity of Tinnitus
- Creators
- William Sedley - Newcastle UniversityJehill Parikh - Newcastle UniversityRichard A. E. Edden - Johns Hopkins UniversityValerie Tait - Freeman HospitalAndrew Blamire - Newcastle UniversityTimothy D. Griffiths - Newcastle Univ, Inst Neurosci, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
- Resource Type
- Journal article
- Publication Details
- The Journal of neuroscience, Vol.35(44), pp.14822-14828
- DOI
- 10.1523/JNEUROSCI.2695-15.2015
- PMID
- 26538652
- PMCID
- PMC4635131
- NLM abbreviation
- J Neurosci
- ISSN
- 0270-6474
- eISSN
- 1529-2401
- Publisher
- Soc Neuroscience
- Number of pages
- 7
- Grant note
- MR/J011207/1 / United Kingdom Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) P41EB015909 / NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Biomedical Imaging & Bioengineering (NIBIB) WT091681MA / Wellcome Trust; European Commission NIH R01 EB016089; P41 EB015909 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA MR/J011207/1 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); European Commission MR/K000608/1 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC)
- Language
- English
- Date published
- 11/04/2015
- Academic Unit
- Psychological and Brain Sciences
- Record Identifier
- 9984627342502771
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