Journal article
Human Breast Milk-Derived Extracellular Vesicles Enhance Osteoblast Activation via BMP2/MAPK Signaling Pathways
Journal of medicinal food, Vol.28(10), pp.1047-1059
10/01/2025
DOI: 10.1177/1096620X251360922
PMID: 40711941
Abstract
Human breast milk-derived extracellular vesicles (HMEVs) have various physiological functions, including immune regulation, cell regeneration, and inflammation suppression, as well as potential therapeutic applications; however, research on the role of HMEVs in bone growth and bone remodeling is insufficient. This study examined the effects of extracellular vesicles derived from human breast milk on osteoblast differentiation and mineralization and elucidated their role in the prevention and treatment of osteoporosis. The study's results showed that HMEVs significantly enhance osteoblast proliferation, differentiation, and mineralization, as confirmed by increased expression of proteins and genes related to bone formation. These effects are mediated via the bone morphogenetic protein 2 (BMP2) and mitogen-activated protein kinase (MAPK) signaling pathways. In other words, this study suggests that HMEVs may have a beneficial effect on the prevention and treatment of osteoporosis by promoting differentiation and mineralization of bone cells through the BMP2 and MAPK signaling pathways.
Details
- Title: Subtitle
- Human Breast Milk-Derived Extracellular Vesicles Enhance Osteoblast Activation via BMP2/MAPK Signaling Pathways
- Creators
- Jae-Hee Kwon - Gyeongguk National UniversityHayeon Jang - Gyeongguk National UniversityJi-Su Kim - Gyeongguk National UniversitySang-Hoon Lee - Gyeongguk National UniversityDong-Ha Kim - Gyeongguk National UniversityYoung-Eun Cho - University of IowaHan-Saem Park - Korea Human Milk Institute, Seoul, South KoreaYoung-Eun Cho - Gyeongguk National University
- Resource Type
- Journal article
- Publication Details
- Journal of medicinal food, Vol.28(10), pp.1047-1059
- DOI
- 10.1177/1096620X251360922
- PMID
- 40711941
- NLM abbreviation
- J Med Food
- ISSN
- 1096-620X
- eISSN
- 1557-7600
- Publisher
- MARY ANN LIEBERT, INC
- Grant note
- National Research Foundation of Korea (NRF) - Korea government (MSIT): 2024-00340542
This work was supported by National Research Foundation of Korea (NRF) grant funded by Korea government (MSIT)(No. 2024-00340542).
- Language
- English
- Electronic publication date
- 07/24/2025
- Date published
- 10/01/2025
- Academic Unit
- Nursing; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984927216502771
Metrics
7 Record Views