Journal article
Human Genetic Determinants of Viral Diseases
Annual review of genetics, Vol.51(1), pp.241-263
11/27/2017
DOI: 10.1146/annurev-genet-120116-023425
PMCID: PMC6038703
PMID: 28853921
Abstract
Much progress has been made in the identification of specific human gene variants that contribute to enhanced susceptibility or resistance to viral diseases. Herein we review multiple discoveries made with genome-wide or candidate gene approaches that have revealed significant insights into virus-host interactions. Genetic factors that have been identified include genes encoding virus receptors, receptor-modifying enzymes, and a wide variety of innate and adaptive immunity-related proteins. We discuss a range of pathogenic viruses, including influenza virus, respiratory syncytial virus, human immunodeficiency virus, human T cell leukemia virus, human papilloma virus, hepatitis B and C viruses, herpes simplex virus, norovirus, rotavirus, parvovirus, and Epstein-Barr virus. Understanding the genetic underpinnings that affect infectious disease outcomes should allow tailored treatment and prevention approaches in the future.
Details
- Title: Subtitle
- Human Genetic Determinants of Viral Diseases
- Creators
- Adam D Kenney - Department of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio 43210, USA; email: Adam.Kenney@osumc.edu , Temet.McMichael@osumc.edu , Anderson.3196@osu.edu , Jacob.Yount@osumc.eduJames A Dowdle - Department of Cancer Biology and Genetics, The Ohio State University, Columbus, Ohio 43210, USA; email: James.Dowdle@osumc.eduLeonia Bozzacco - Current affiliation: Target Information Group, Regeneron Pharmaceuticals, Inc., Tarrytown, New York 10591, USA; email: leonia.bozzacco@gmail.comTemet M McMichael - Department of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio 43210, USA; email: Adam.Kenney@osumc.edu , Temet.McMichael@osumc.edu , Anderson.3196@osu.edu , Jacob.Yount@osumc.eduCorine St Gelais - Center of Retrovirus Research, Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210, USA; email: St-gelais.2@osu.edu , Panfil.6@osu.edu , Green.466@osu.edu , Wu.840@osu.eduAmanda R Panfil - Center of Retrovirus Research, Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210, USA; email: St-gelais.2@osu.edu , Panfil.6@osu.edu , Green.466@osu.edu , Wu.840@osu.eduYan Sun - Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA; email: Yansun@vet.upenn.edu , Lopezca@vet.upenn.eduLarry S Schlesinger - Texas Biomedical Research Institute, San Antonio, Texas 78227, USA; email: lschlesinger@txbiomed.orgMatthew Z Anderson - Department of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio 43210, USA; email: Adam.Kenney@osumc.edu , Temet.McMichael@osumc.edu , Anderson.3196@osu.edu , Jacob.Yount@osumc.eduPatrick L Green - Center of Retrovirus Research, Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210, USA; email: St-gelais.2@osu.edu , Panfil.6@osu.edu , Green.466@osu.edu , Wu.840@osu.eduCarolina B López - Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA; email: Yansun@vet.upenn.edu , Lopezca@vet.upenn.eduBrad R Rosenberg - Current affiliation: Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; email: brad.rosenberg@mssm.eduLi Wu - Center of Retrovirus Research, Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210, USA; email: St-gelais.2@osu.edu , Panfil.6@osu.edu , Green.466@osu.edu , Wu.840@osu.eduJacob S Yount - Department of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio 43210, USA; email: Adam.Kenney@osumc.edu , Temet.McMichael@osumc.edu , Anderson.3196@osu.edu , Jacob.Yount@osumc.edu
- Resource Type
- Journal article
- Publication Details
- Annual review of genetics, Vol.51(1), pp.241-263
- Publisher
- United States
- DOI
- 10.1146/annurev-genet-120116-023425
- PMID
- 28853921
- PMCID
- PMC6038703
- ISSN
- 0066-4197
- eISSN
- 1545-2948
- Grant note
- R01 AI104483 / NIAID NIH HHS R21 CA181997 / NCI NIH HHS U19 AI111825 / NIAID NIH HHS R56 AI127667 / NIAID NIH HHS R01 AI120209 / NIAID NIH HHS T32 GM068412 / NIGMS NIH HHS R01 AI130110 / NIAID NIH HHS
- Language
- English
- Date published
- 11/27/2017
- Academic Unit
- Microbiology and Immunology
- Record Identifier
- 9984001224602771
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