Journal article
Human Milk Use in the Preoperative Period Is Associated with a Lower Risk for Necrotizing Enterocolitis in Neonates with Complex Congenital Heart Disease
The Journal of pediatrics, Vol.215, pp.11-16
12/01/2019
DOI: 10.1016/j.jpeds.2019.08.009
PMCID: PMC7294855
PMID: 31561958
Abstract
Objective To evaluate the hypothesis that feeding volumes exceeding 100 mL/kg/d and exposure to cow's milk formula preoperatively increase the risk for preoperative necrotizing enterocolitis (NEC) in infants with complex congenital heart disease.
Study design All infants, of any gestational age, with an isolated cardiac lesion at high risk for NEC (ductal-dependent lesions, transposition of the great arteries, truncus arteriosus, and aorto-pulmonary window) admitted to Texas Children's Hospital from 2010 to 2016 were included. NEC was defined based on the modified Bell criteria. Feeding regimen information and relevant covariates were collected. Logistic regression was used to evaluate the association of feeding regimen and other potential risk factors with NEC.
Results In this single-center, retrospective cohort of 546 infants, 3.3% developed Bell stage I-Ill NEC preoperatively. An exclusive unfortified human milk diet was associated with a significantly lower risk of preoperative NEC (OR 0.17, 95% CI 0.04-0.84, P = .03) in a multivariable regression model controlling for cardiac lesion, race, feeding volume, birth weight small for gestational age, inotrope use presurgery/pre-NEC, and prematurity. Feeding volumes exceeding 100 mL/kg/d were associated with a significantly greater risk of preoperative NEC (OR 3.05, 95% CI 1.19-7.90, P = .02).
Conclusions The findings suggest that an unfortified exclusive human milk diet may reduce the risk of preoperative NEC in infants with complex congenital heart disease.
Details
- Title: Subtitle
- Human Milk Use in the Preoperative Period Is Associated with a Lower Risk for Necrotizing Enterocolitis in Neonates with Complex Congenital Heart Disease
- Creators
- Acacia Cognata - Texas Children's HospitalJasmeet Kataria-Hale - Texas Children's HospitalPamela Griffiths - Texas Children's HospitalShiraz Maskatia - Texas Children's HospitalDanielle Rios - Texas Children's HospitalAndrea O'Donnell - Texas Children's HospitalDantin J. Roddy - Texas Children's HospitalAmy Mehollin-Ray - Texas Children's HospitalJoseph Hagan - Texas Children's HospitalJennifer Placencia - Texas Children's HospitalAmy B. Hair - Texas Children's Hospital
- Resource Type
- Journal article
- Publication Details
- The Journal of pediatrics, Vol.215, pp.11-16
- DOI
- 10.1016/j.jpeds.2019.08.009
- PMID
- 31561958
- PMCID
- PMC7294855
- NLM abbreviation
- J Pediatr
- ISSN
- 0022-3476
- eISSN
- 1097-6833
- Publisher
- Elsevier
- Number of pages
- 6
- Grant note
- Texas Children's Hospital (Evie Whitlock Grant) 1K23HLI130522 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Language
- English
- Date published
- 12/01/2019
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology
- Record Identifier
- 9984353947302771
Metrics
22 Record Views