Human Papillomavirus Detection in Scrotal Squamous Cell Carcinoma: Case Series from a Population-Based Cancer Registry

Jacqueline M. Mix; Maureen J. Miller; Troy D. Querec; Teresa M. Darragh; Mona Saraiya; Sameer V. Gopalani; Charles F. Lynch; Trevor D. Thompson; April Greek; Thomas C. Tucker; Edward S. Peters; Elizabeth R. Unger

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Human Papillomavirus Detection in Scrotal Squamous Cell Carcinoma: Case Series from a Population-Based Cancer Registry

Journal article

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Human Papillomavirus Detection in Scrotal Squamous Cell Carcinoma: Case Series from a Population-Based Cancer Registry

Jacqueline M. Mix, Maureen J. Miller, Troy D. Querec, Teresa M. Darragh, Mona Saraiya, Sameer V. Gopalani, Charles F. Lynch, Trevor D. Thompson, April Greek, Thomas C. Tucker, …

Journal of registry management, Vol.50(4), pp.116-121

01/01/2023

PMCID: PMC10945928

PMID: 38504701

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10945928/View

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Abstract

Abstract: Introduction: Scrotal squamous cell carcinomas (SCCs) are rare malignancies that are not considered to be associated with the human papillomavirus (HPV) by the International Agency for Research on Cancer. However, recent studies have detected HPV in these cancers. We sought to determine the presence of HPV types among scrotal cancer cases identified through population-based cancer registries. Methods: Primary scrotal SCCs diagnosed from 2014 to 2015 were identified, and tissue sections from formalin-fixed, paraffin-embedded tissue blocks were obtained for laboratory testing. A pathology review was performed to confirm morphology. HPV testing was performed using L1 consensus polymerase chain reaction analysis. Immunohistochemistry was used to evaluate p16INK4a (p16) expression. Results: Five cases of scrotal SCC were identified from 1 cancer registry. Age at diagnosis ranged from 34 to 75 years (median, 56 years). Four cases were non-Hispanic White, and 1 was non-Hispanic Black. The morphologic subtype of 4 cases was keratinizing (usual), and 1 case was verrucous (warty) histologic subtype. Two of the usual cases of SCC were HPV-negative and p16-negative, and 2 were positive for HPV16 and p16. The verrucous (warty) SCC subtype case was HPV6-positive and p16-negative. Conclusions: The presence of HPV16 and p16 overexpression in the examined tissue specimens lends additional support for the role of HPV in the etiology of scrotal SCC.

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Title: Subtitle: Human Papillomavirus Detection in Scrotal Squamous Cell Carcinoma: Case Series from a Population-Based Cancer Registry
Creators: Jacqueline M. Mix - Oak Ridge Institute for Science and Education
Maureen J. Miller - Centers for Disease Control and Prevention, Atlanta, Georgia
Troy D. Querec - Centers for Disease Control and Prevention, Atlanta, Georgia
Teresa M. Darragh - University of California, San Francisco
Mona Saraiya - Centers for Disease Control and Prevention
Sameer V. Gopalani - Oak Ridge Institute for Science and Education
Charles F. Lynch - University of Iowa
Trevor D. Thompson - Centers for Disease Control and Prevention, Atlanta, Georgia
April Greek - Battelle, Seattle, Washington
Thomas C. Tucker - University of Kentucky
Edward S. Peters - Louisiana State University Health Sciences Center New Orleans
Elizabeth R. Unger - Centers for Disease Control and Prevention
Resource Type: Journal article
Publication Details: Journal of registry management, Vol.50(4), pp.116-121
Publisher: National Cancer Registrars Association
PMID: 38504701
PMCID: PMC10945928
ISSN: 1945-6123
eISSN: 1945-6131
Grant note: ;
Language: English
Date published: 01/01/2023
Academic Unit: Epidemiology
Record Identifier: 9984573558102771

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