Journal article
Human Papillomavirus Genotype Prevalence in Invasive Penile Cancers from a Registry-Based United States Population
Frontiers in Oncology, Vol.4, 9
02/01/2014
DOI: 10.3389/fonc.2014.00009
PMCID: PMC3914298
PMID: 24551592
Abstract
Background. Human papillomavirus (HPV) is estimated to play an etiologic role in 40%-50% of penile cancers worldwide. Estimates of HPV prevalence in U.S. penile cancer cases are limited. Methods. HPV DNA was evaluated in tumor tissue from 79 invasive penile cancer patients diagnosed in 1998-2005 within the catchment areas of 7 U.S. cancer registries. HPV was genotyped using PCR-based Linear Array and INNO-LiPA assays and compared by demographic, clinical, and pathologic characteristics and survival. Histological classification was also obtained by independent pathology review. Results. HPV DNA was present in 50 of 79 (63%) of invasive penile cancer cases. Sixteen viral genotypes were detected. HPV 16, found in 46% (36/79) of all cases (72% of HPV-positive cases) was the most prevalent genotype followed equally by HPV 18, 33, and 45, which each comprised 5% of all cases. Multiple genotypes were detected in 18% of viral positive cases. HPV prevalence did not significantly vary by age, race/ethnicity, population size of geographic region, cancer stage, histology, grade, penile subsite, or prior cancer history. Penile cases diagnosed in more recent years were more likely to be HPV positive. Overall survival did not significantly vary by HPV status. Conclusions. The relatively high prevalence of HPV in our study population provides limited evidence of a more prominent and, possibly, increasing role of infection in penile carcinogenesis in the U.S. compared to other parts of the world.
Details
- Title: Subtitle
- Human Papillomavirus Genotype Prevalence in Invasive Penile Cancers from a Registry-Based United States Population
- Creators
- Brenda Y Hernandez - University of Hawaii SystemMarc T Goodman - Cedars-Sinai Medical CenterElizabeth R Unger - Centers for Disease Control and PreventionMartin Steinau - Centers for Disease Control and PreventionAmy PowersCharles F Lynch - University of Iowa, EpidemiologyWendy Cozen - University of Southern CaliforniaMaria Sibug SaberEdward S PetersEdward J Wilkinson - University of FloridaGlenn CopelandClaudia Hopenhayn - University of KentuckyYoujie Huang - Florida Department of HealthMeg Watson - National Center for Chronic Disease Prevention and Health PromotionSean F Altekruse - National Cancer InstituteChristopher LyuMona Saraiya - National Center for Chronic Disease Prevention and Health Promotion
- Resource Type
- Journal article
- Publication Details
- Frontiers in Oncology, Vol.4, 9
- DOI
- 10.3389/fonc.2014.00009
- PMID
- 24551592
- PMCID
- PMC3914298
- NLM abbreviation
- Front Oncol
- ISSN
- 2234-943X
- eISSN
- 2234-943X
- Publisher
- Frontiers Media S.A
- Grant note
- 5U58DP000769-05 / National Institutes of Health (nih_________::NIH) 5U58DP000844-03 / National Institutes of Health (nih_________::NIH) 5U58DP000812-05 / National Institutes of Health (nih_________::NIH) 5U58DP000807-03 / National Institutes of Health (nih_________::NIH) 1U58DP000810-01 / National Institutes of Health (nih_________::NIH)
- Language
- English
- Date published
- 02/01/2014
- Academic Unit
- Epidemiology
- Record Identifier
- 9984216739602771
Metrics
10 Record Views