Journal article
Human Papillomavirus-Positive Oral Cavity and Oropharyngeal Cancer Patients Do Not Have Better Quality-of-Life Trajectories
Otolaryngology-head and neck surgery, Vol.146(5), pp.739-745
05/01/2012
DOI: 10.1177/0194599811434707
PMCID: PMC3535430
PMID: 22275190
Abstract
Objective. To determine the role of human papillomavirus (HPV) status on quality of life (QOL) in patients with oral cavity and oropharyngeal squamous cell carcinoma (OSCC). Since OSCC that are associated with high-risk HPV have an improved response to treatment and survival, we hypothesized that patients with these tumors would have better QOL trajectories.
Study Design. Prospective cohort study.
Setting. Tertiary care academic medical center and 2 affiliated hospitals.
Subjects and Methods. Head and neck-specific QOL was determined using the University of Washington Quality of Life scale version 4 in patients with newly diagnosed invasive OSSC (N = 228).
Results. Pretreatment QOL was higher in patients with high-risk HPV-associated tumors compared with patients with HPV-negative or low-risk HPV-associated tumors (P = .015). Patients with high-risk HPV-associated tumors had larger decreases in QOL from pretreatment to immediate post-treatment compared with patients with HPV-negative or low-risk HPV-associated tumors (P = .041). There was no association between HPV status and 1-year posttreatment QOL.
Conclusion. Among OSCC patients, high-risk HPV-associated tumors were associated with higher pretreatment QOL and a larger decrease in QOL from pretreatment to immediate posttreatment, suggesting that treatment intensity in this unique population may adversely affect QOL.
Details
- Title: Subtitle
- Human Papillomavirus-Positive Oral Cavity and Oropharyngeal Cancer Patients Do Not Have Better Quality-of-Life Trajectories
- Creators
- Arun Sharma - University of WashingtonEduardo Mendez - Fred Hutch Cancer CenterBevan Yueh - University of MinnesotaPawadee Lohavanichbutr - Fred Hutch Cancer CenterJohn Houck - Fred Hutch Cancer CenterDavid R. Doody - Fred Hutch Cancer CenterNeal D. Futran - University of WashingtonMelissa P. Upton - University of WashingtonStephen M. Schwartz - University of WashingtonChu Chen - University of Washington
- Resource Type
- Journal article
- Publication Details
- Otolaryngology-head and neck surgery, Vol.146(5), pp.739-745
- DOI
- 10.1177/0194599811434707
- PMID
- 22275190
- PMCID
- PMC3535430
- NLM abbreviation
- Otolaryngol Head Neck Surg
- ISSN
- 0194-5998
- eISSN
- 1097-6817
- Publisher
- Sage
- Number of pages
- 7
- Grant note
- KL2 RR025015; KL2 RR025015-01; 1K1L2RR025015-01 / NCRR NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) R01 CA095419; R01CA095419 / NCI NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) R01CA095419 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) KL2RR025015 / NATIONAL CENTER FOR RESEARCH RESOURCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR)
- Language
- English
- Date published
- 05/01/2012
- Academic Unit
- Otolaryngology
- Record Identifier
- 9984966851402771
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