Journal article
Human Pegivirus Infection and Lymphoma Risk: A Systematic Review and Meta-analysis
Clinical infectious diseases, Vol.71(5), pp.1221-1228
08/22/2020
DOI: 10.1093/cid/ciz940
PMCID: PMC7442854
PMID: 31671178
Abstract
Human pegivirus (HPgV) is a single-strand RNA virus belonging to the Flaviviridae. Although no definitive association between HPgV infection and disease has been identified, previous studies have suggested an association of HPgV viremia with risk of lymphomas.
We conducted a systematic review and meta-analysis, including 1 cohort study and 14 case-control studies, assessing the association of HPgV viremia with adult lymphomas. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using a random-effects model, overall and by geographic region and lymphoma subtype.
The overall OR for lymphoma was 2.85 (95% CI, 1.98-4.11), with statistically significantly elevated ORs observed in 8 of 15 studies. There was a small amount of heterogeneity among studies (I2 = 28.9%; Q = 18.27, P = .16), and the funnel plot provided no evidence for publication bias. The strongest association with lymphoma risk was observed for studies from Southern Europe (OR, 5.68 [95% CI, 1.98-16.3]), whereas weaker ORs (with 95% CIs) were observed for studies from North America (2.24 [1.76-2.85]), Northern Europe (2.90 [.45-18.7), and the Middle East (2.51 [.87-7.27]), but all of similar magnitude. Participants with HPgV viremia had statistically significantly increased risks (OR [95% CI]) for developing diffuse large B-cell (3.29 [1.63-6.62]), follicular (3.01 [1.95-4.63]), marginal zone (1.90 [1.13-3.18]), and T-cell (2.11 [1.17-3.89]) lymphomas, while the risk for Hodgkin lymphoma (3.53 [.48-25.9]) and chronic lymphocytic leukemia (1.45 [.45-4.66]) were increased but did not achieve statistical significance.
This meta-analysis supports a positive association of HPgV viremia with lymphoma risk, overall and for the major lymphoma subtypes.
Details
- Title: Subtitle
- Human Pegivirus Infection and Lymphoma Risk: A Systematic Review and Meta-analysis
- Creators
- Angelo Fama - Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.Melissa C Larson - Mayo Clinic in FloridaBrian K Link - University of IowaThomas M Habermann - Mayo ClinicAndrew L Feldman - Mayo ClinicTimothy G Call - Mayo ClinicStephen M Ansell - Mayo ClinicMark Liebow - Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota,USA.Jinhua Xiang - Veterans Health AdministrationMatthew J Maurer - Mayo ClinicSusan L Slager - Mayo Clinic in FloridaGrzegorz S Nowakowski - Mayo ClinicJack T Stapleton - University of IowaJames R Cerhan - Mayo Clinic
- Resource Type
- Journal article
- Publication Details
- Clinical infectious diseases, Vol.71(5), pp.1221-1228
- DOI
- 10.1093/cid/ciz940
- PMID
- 31671178
- PMCID
- PMC7442854
- NLM abbreviation
- Clin Infect Dis
- ISSN
- 1058-4838
- eISSN
- 1537-6591
- Grant note
- U01 CA195568 / NCI NIH HHS P30 CA086862 / NCI NIH HHS P50 CA097274 / NCI NIH HHS
- Language
- English
- Date published
- 08/22/2020
- Academic Unit
- Microbiology and Immunology; Infectious Diseases; Hematology, Oncology, and Blood & Marrow Transplantation; Epidemiology; Internal Medicine
- Record Identifier
- 9984297319702771
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