Journal article
Human Pegivirus infection and lymphoma risk and prognosis: a North American study
British journal of haematology, Vol.182(5), pp.644-653
09/01/2018
DOI: 10.1111/bjh.15416
PMCID: PMC6108902
PMID: 29808922
Abstract
We evaluated the association of Human Pegivirus (HPgV) viraemia with risk of developing lymphoma, overall and by major subtypes. Because this virus has also been associated with better prognosis in the setting of co-infection with human immunodeficiency virus, we further assessed the association of HPgV with prognosis. We used risk factor data and banked plasma samples from 2094 lymphoma cases newly diagnosed between 2002 and 2009 and 1572 frequency-matched controls. Plasma samples were tested for HPgV RNA by reverse transcription polymerase chain reaction (RT-PCR), and those with RNA concentrations <5000 genome equivalents/ml were confirmed using nested RT-PCR methods. To assess the role of HPgV in lymphoma prognosis, we used 2948 cases from a cohort study of newly diagnosed lymphoma patients (included all cases from the case-control study). There was a positive association of HPgV viraemia with risk of lymphoma overall (Odds ratio=214; 95% confidence interval [CI] 163-280; P<00001), and for all major subtypes except Hodgkin lymphoma and chronic lymphocytic leukaemia/small lymphocytic lymphoma, and this was not confounded by other lymphoma risk factors. In contrast, there was no association of HPgV viraemia with event-free survival (Hazard ratio [HR]=100; 95% CI 085-118) or overall survival (HR=097; 95% CI 079-120) for lymphoma overall, or any of the subtypes. These data support the hypothesis for a role of HPgV in the aetiology of multiple lymphoma subtypes.
Details
- Title: Subtitle
- Human Pegivirus infection and lymphoma risk and prognosis: a North American study
- Creators
- Angelo Fama - Division of Hematology Department of Internal Medicine Mayo Clinic Rochester MN USAJinhua Xiang - University of IowaBrian K. Link - University of IowaCristine Allmer - Mayo Clinic in FloridaDonna Klinzman - University of IowaAndrew L. Feldman - Mayo ClinicGrzegorz S. Nowakowski - Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA,Mark Liebow - Department of Internal Medicine, Mayo Clinic, Rochester MN, USA;Melissa C. Larson - Mayo Clinic in FloridaMatthew J. Maurer - Mayo Clin, Dept Hlth Sci Res, 200 First St SW, Rochester, MN 55901 USAStephen M. Ansell - Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA,Anne J. Novak - Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA,Yan W. Asmann - Mayo Clinic in FloridaSusan L. Slager - Mayo Clinic in FloridaTimothy G. Call - Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA,Thomas M. Habermann - Mayo ClinicJames R. Cerhan - Mayo Clinic in FloridaJack T. Stapleton - University of Iowa
- Resource Type
- Journal article
- Publication Details
- British journal of haematology, Vol.182(5), pp.644-653
- DOI
- 10.1111/bjh.15416
- PMID
- 29808922
- PMCID
- PMC6108902
- NLM abbreviation
- Br J Haematol
- ISSN
- 0007-1048
- eISSN
- 1365-2141
- Publisher
- Wiley
- Number of pages
- 10
- Grant note
- I01CX000821 / Veterans Affairs; US Department of Veterans Affairs CX00821; BX000207 / Department of Veterans Affairs Merit Review Grants; US Department of Veterans Affairs P50 CA97274; U01 CA195568 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA U01CA195568 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
- Language
- English
- Date published
- 09/01/2018
- Academic Unit
- Microbiology and Immunology; Infectious Diseases; Hematology, Oncology, and Blood & Marrow Transplantation; Epidemiology; Internal Medicine
- Record Identifier
- 9984297321502771
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