Journal article
Human adipose-derived mesenchymal stern cells attenuate liver ischemia-reperfusion injury and promote liver regeneration
Surgery, Vol.156(5), pp.1225-1231
11/01/2014
DOI: 10.1016/j.surg.2014.05.008
PMID: 25262218
Abstract
Background. Ischemia-reperfusion injury (IRI) of the liver is a well-known cause of morbidity and mortality after liver transplantation. Effective treatment strategies aimed at decreasing hepatic IRI injury and accelerating liver regeneration could offer major benefits in liver transplantation, especially in the case of partial allografts. Human adipose derived mesenchymal stem cells (HADMSCs) are an attractive source for regenerative medicine because of their anti-inflammatory and regenerative properties. We hypothesized that HADMSCs attenuate IRI and promote liver regeneration.
Methods. Mice were subjected to 60 minutes of partial IRI with or without 70% partial hepatectomy. Animals were treated with HADMSCs. Liver IRI was evaluated with serum levels of alanine aminotransferase, serum interleukin-6, and histopathology. Liver samples were stained for specific markers of liver regeneration.
Results. Histology, serum interleukin-6, and alanine aminotransferase release revealed that treatment with HADMSCs attenuated liver injury compared with control patients. Improved animal survival and increased number of regenerating cells were observed in HADMSC-treated animals who underwent IRI and partial hepatectomy compared with the control group.
Conclusion. HADMSC represents a potential therapeutic strategy to decrease IRI and promote regeneration in liver transplantation.
Details
- Title: Subtitle
- Human adipose-derived mesenchymal stern cells attenuate liver ischemia-reperfusion injury and promote liver regeneration
- Creators
- Reza F. Saidi - Brown UniversityBarur Rajeshkumar - University of Massachusetts Medical SchoolAhmad Shariftabrizi - University of Massachusetts Chan Medical SchoolAlexei A. Bogdanov - University of Massachusetts Medical SchoolShaokuan Zheng - University of Massachusetts Medical SchoolKaren Dresser - University of Massachusetts Medical SchoolOtto Walter - University of Massachusetts Medical School
- Resource Type
- Journal article
- Publication Details
- Surgery, Vol.156(5), pp.1225-1231
- Publisher
- Elsevier
- DOI
- 10.1016/j.surg.2014.05.008
- PMID
- 25262218
- ISSN
- 0039-6060
- eISSN
- 1532-7361
- Number of pages
- 7
- Language
- English
- Date published
- 11/01/2014
- Academic Unit
- Radiology
- Record Identifier
- 9984318688002771
Metrics
6 Record Views