Journal article
Human airway branch variation and chronic obstructive pulmonary disease
Proceedings of the National Academy of Sciences - PNAS, Vol.115(5), pp.E974-E981
01/30/2018
DOI: 10.1073/pnas.1715564115
PMCID: PMC5798356
PMID: 29339516
Abstract
Susceptibility to chronic obstructive pulmonary disease (COPD) beyond cigarette smoking is incompletely understood, although several genetic variants associated with COPD are known to regulate airway branch development. We demonstrate that in vivo central airway branch variants are present in 26.5% of the general population, are unchanged over 10 y, and exhibit strong familial aggregation. The most common airway branch variant is associated with COPD in two cohorts (
= 5,054), with greater central airway bifurcation density, and with emphysema throughout the lung. The second most common airway branch variant is associated with COPD among smokers, with narrower airway lumens in all lobes, and with genetic polymorphisms within the
gene. We conclude that central airway branch variation, readily detected by computed tomography, is a biomarker of widely altered lung structure with a genetic basis and represents a COPD susceptibility factor.
Details
- Title: Subtitle
- Human airway branch variation and chronic obstructive pulmonary disease
- Creators
- Benjamin M Smith - Translational Research in Respiratory Diseases Program, Department of Medicine, McGill University Health Centre Research Institute, Montreal, QC H4A 3J1, CanadaHussein Traboulsi - Translational Research in Respiratory Diseases Program, Department of Medicine, McGill University Health Centre Research Institute, Montreal, QC H4A 3J1, CanadaJohn H M Austin - Department of Radiology, College of Physicians and Surgeons, Columbia University, New York, NY 10032Ani Manichaikul - Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22903Eric A Hoffman - Department of Biomedical Engineering, University of Iowa, Iowa City, IA 52242Eugene R Bleecker - Department of Medicine, Wake Forest University, Winston-Salem, NC 27101Wellington V Cardoso - Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032Christopher Cooper - Department of Medicine, University of California, Los Angeles, CA 90095David J Couper - Department of Biostatistics, University of North Carolina at Chapel HIll, Chapel Hill, NC 27599Stephen M Dashnaw - Department of Radiology, College of Physicians and Surgeons, Columbia University, New York, NY 10032Jia Guo - Department of Biomedical Engineering, Columbia University, New York, NY 10027MeiLan K Han - Department of Medicine, University of Michigan, Ann Arbor, MI 48109Nadia N Hansel - Department of Medicine, Johns Hopkins University, Baltimore, MD 21205Emlyn W Hughes - Department of Physics, Columbia University, New York, NY 10027David R Jacobs Jr - Division of Epidemiology and Community Public Health, School of Public Health, University of Minnesota, Minneapolis, MN 55454Richard E Kanner - Department of Medicine, University of Utah, Salt Lake City, UT 84132Joel D Kaufman - Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98195Eric Kleerup - Department of Medicine, University of California, Los Angeles, CA 90095Ching-Long Lin - Department of Mechanical and Industrial Engineering, College of Engineering, University of Iowa, Iowa City, IA 52242Kiang Liu - Department of Medicine, Northwestern University, Chicago, IL 60611Christian M Lo Cascio - Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032Fernando J Martinez - Department of Medicine, Weill Cornell Medical College, New York, NY 10065Jennifer N Nguyen - Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22903Martin R Prince - Department of Radiology, College of Physicians and Surgeons, Columbia University, New York, NY 10032Stephen Rennard - Department of Medicine, University of Nebraska Medical Center, Omaha, NE 68198Stephen S Rich - Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22903Leora Simon - Translational Research in Respiratory Diseases Program, Department of Medicine, McGill University Health Centre Research Institute, Montreal, QC H4A 3J1, CanadaYanping Sun - Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032Karol E Watson - Department of Medicine, University of California, Los Angeles, CA 90095Prescott G Woodruff - Department of Medicine, University of California, San Francisco, CA 94110Carolyn J Baglole - Translational Research in Respiratory Diseases Program, Department of Medicine, McGill University Health Centre Research Institute, Montreal, QC H4A 3J1, CanadaR Graham Barr - Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032
- Resource Type
- Journal article
- Publication Details
- Proceedings of the National Academy of Sciences - PNAS, Vol.115(5), pp.E974-E981
- DOI
- 10.1073/pnas.1715564115
- PMID
- 29339516
- PMCID
- PMC5798356
- NLM abbreviation
- Proc Natl Acad Sci U S A
- ISSN
- 0027-8424
- eISSN
- 1091-6490
- Publisher
- National Academy of Sciences; United States
- Grant note
- U01 HL114494 / NHLBI NIH HHS HHSN268200900019C / NHLBI NIH HHS N01HC95169 / NHLBI NIH HHS HHSN268200900020C / NHLBI NIH HHS N01HC95161 / NHLBI NIH HHS HHSN268200900015C / NHLBI NIH HHS N01HC95164 / NHLBI NIH HHS N01HC95167 / NHLBI NIH HHS RC1 HL100543 / NHLBI NIH HHS N01HC95159 / NHLBI NIH HHS HHSN268200900018C / NHLBI NIH HHS HHSN268200900014C / NHLBI NIH HHS N01HC95163 / NHLBI NIH HHS R01 HL077612 / NHLBI NIH HHS N01HC95166 / NHLBI NIH HHS R35 HL135834 / NHLBI NIH HHS HHSN268200900017C / NHLBI NIH HHS U01 HL137880 / NHLBI NIH HHS R01 HL130506 / NHLBI NIH HHS HHSN268200900013C / NHLBI NIH HHS R01 HL093081 / NHLBI NIH HHS N01HC95160 / NHLBI NIH HHS R01 HL112986 / NHLBI NIH HHS R01 HL121270 / NHLBI NIH HHS K24 HL137013 / NHLBI NIH HHS HHSN268200900016C / NHLBI NIH HHS N01HC95168 / NHLBI NIH HHS N01HC95165 / NHLBI NIH HHS P30 DK054759 / NIDDK NIH HHS N01HC95162 / NHLBI NIH HHS
- Language
- English
- Date published
- 01/30/2018
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Mechanical Engineering; Internal Medicine
- Record Identifier
- 9984051556302771
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